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Role of Macrophages in Brain Tumor Growth and Progression

Department of Advanced Biomedical Sciences—Pathology Section, University of Naples “Federico II”—via Pansini 5, 80131 Naples, Italy
Department of Health Sciences, University of Catanzaro “Magna Græcia”—viale Europa, 88100 Catanzaro, Italy
Department of Medical and Surgical Sciences—University of Catanzaro “Magna Graecia”—viale Europa, 88100 Catanzaro, Italy
Department of Clinical and Experimental Medicine—University of Catanzaro “Magna Graecia”—viale Europa, 88100 Catanzaro, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 1005;
Received: 3 February 2018 / Revised: 10 March 2018 / Accepted: 23 March 2018 / Published: 27 March 2018
(This article belongs to the Special Issue Macrophages in Inflammation)
The role of macrophages in the growth and the progression of tumors has been extensively studied in recent years. A large body of data demonstrates that macrophage polarization plays an essential role in the growth and progression of brain tumors, such as gliomas, meningiomas, and medulloblastomas. The brain neoplasm cells have the ability to influence the polarization state of the tumor associated macrophages. In turn, innate immunity cells have a decisive role through regulation of the acquired immune response, but also through humoral cross-talking with cancer cells in the tumor microenvironment. Neoangiogenesis, which is an essential element in glial tumor progression, is even regulated by the tumor associated macrophages, whose activity is linked to other factors, such as hypoxia. In addition, macrophages play a decisive role in establishing the entry into the bloodstream of cancer cells. As is well known, the latter phenomenon is also present in brain tumors, even if they only rarely metastasize. Looking ahead in the future, we can imagine that characterizing the relationships between tumor and tumor associated macrophage, as well as the study of circulating tumor cells, could give us useful tools in prognostic evaluation and therapy. More generally, the study of innate immunity in brain tumors can boost the development of new forms of immunotherapy. View Full-Text
Keywords: meningioma; macrophage polarization; innate immunity; cancer; glioma; medulloblastoma meningioma; macrophage polarization; innate immunity; cancer; glioma; medulloblastoma
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MDPI and ACS Style

Guadagno, E.; Presta, I.; Maisano, D.; Donato, A.; Pirrone, C.K.; Cardillo, G.; Corrado, S.D.; Mignogna, C.; Mancuso, T.; Donato, G.; Del Basso De Caro, M.; Malara, N. Role of Macrophages in Brain Tumor Growth and Progression. Int. J. Mol. Sci. 2018, 19, 1005.

AMA Style

Guadagno E, Presta I, Maisano D, Donato A, Pirrone CK, Cardillo G, Corrado SD, Mignogna C, Mancuso T, Donato G, Del Basso De Caro M, Malara N. Role of Macrophages in Brain Tumor Growth and Progression. International Journal of Molecular Sciences. 2018; 19(4):1005.

Chicago/Turabian Style

Guadagno, Elia; Presta, Ivan; Maisano, Domenico; Donato, Annalidia; Pirrone, Caterina K.; Cardillo, Gabriella; Corrado, Simona D.; Mignogna, Chiara; Mancuso, Teresa; Donato, Giuseppe; Del Basso De Caro, Marialaura; Malara, Natalia. 2018. "Role of Macrophages in Brain Tumor Growth and Progression" Int. J. Mol. Sci. 19, no. 4: 1005.

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