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Int. J. Mol. Sci. 2018, 19(3), 790; https://doi.org/10.3390/ijms19030790

Virucidal or Not Virucidal? That Is the Question—Predictability of Ionic Liquid’s Virucidal Potential in Biological Test Systems

1
Christian Doppler-Laboratory for Monitoring of Microbial Contaminants, Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria
2
Institute of Milk Hygiene, Milk Technology and Food Science, Department for Farm Animal and Public Veterinary Health, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria
3
Proionic Production of Ionic Substances GmbH, 8074 Grambach, Austria
*
Author to whom correspondence should be addressed.
Received: 30 January 2018 / Revised: 26 February 2018 / Accepted: 4 March 2018 / Published: 9 March 2018
(This article belongs to the Special Issue Ionic Liquids 2018 and Selected Papers from ILMAT IV)
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Abstract

For three decades now, ionic liquids (ILs), organic salts comprising only ions, have emerged as a new class of pharmaceuticals. Although recognition of the antimicrobial effects of ILs is growing rapidly, there is almost nothing known about their possible virucidal activities. This probably reflects the paucity of understanding virus inactivation. In this study, we performed a systematic analysis to determine the effect of specific structural motifs of ILs on three different biological test systems (viruses, bacteria and enzymes). Overall, the effects of 27 different ILs on two non-enveloped and one enveloped virus (P100, MS2 and Phi6), two Gram negative and one Gram positive bacteria (E. coli, P. syringae and L. monocytogenes) and one enzyme (Taq DNA polymerase) were investigated. Results show that while some ILs were virucidal, no clear structure activity relationships (SARs) could be identified for the non-enveloped viruses P100 and MS2. However, for the first time, a correlation has been demonstrated between the effects of ILs on enveloped viruses, bacteria and enzyme inhibition. These identified SARs serve as a sound starting point for further studies. View Full-Text
Keywords: ionic liquid; disinfectant; virus; P100; MS2; Phi6; SARs; virucide ionic liquid; disinfectant; virus; P100; MS2; Phi6; SARs; virucide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sommer, J.; Fister, S.; Gundolf, T.; Bromberger, B.; Mester, P.-J.; Witte, A.K.; Kalb, R.; Rossmanith, P. Virucidal or Not Virucidal? That Is the Question—Predictability of Ionic Liquid’s Virucidal Potential in Biological Test Systems. Int. J. Mol. Sci. 2018, 19, 790.

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