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Int. J. Mol. Sci. 2018, 19(2), 562; https://doi.org/10.3390/ijms19020562

The Crosstalk between Nrf2 and Inflammasomes

1
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, F30, CH-8091 Zurich, Switzerland
2
Faculty of Medicine, University of Zurich, CH-8091 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Received: 24 January 2018 / Revised: 8 February 2018 / Accepted: 9 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Nrf2 in Redox Signaling: A Double Edged Sword)
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Abstract

The Nrf2 (nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2) transcription factor is a key player in cytoprotection and activated in stress conditions caused by reactive oxygen species (ROS) or electrophiles. Inflammasomes represent central regulators of inflammation. Upon detection of various stress factors, assembly of the inflamasome protein complex results in activation and secretion of proinflammatory cytokines. In addition, inflammasome activation causes pyroptosis, a lytic form of cell death, which supports inflammation. There is growing evidence of a crosstalk between the Nrf2 and inflammasome pathways at different levels. For example, Nrf2 activating compounds inhibit inflammasomes and consequently inflammation. This review summarizes what is known about the complex and predominantly antagonistic relationship of both stress-activated pathways. View Full-Text
Keywords: caspase-1; Nrf2; inflammasome; nucleotide-binding oligomerization domain (NOD)-like receptor containing pyrin domain 3 (NLRP3); inflammation caspase-1; Nrf2; inflammasome; nucleotide-binding oligomerization domain (NOD)-like receptor containing pyrin domain 3 (NLRP3); inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hennig, P.; Garstkiewicz, M.; Grossi, S.; Di Filippo, M.; French, L.E.; Beer, H.-D. The Crosstalk between Nrf2 and Inflammasomes. Int. J. Mol. Sci. 2018, 19, 562.

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