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Int. J. Mol. Sci. 2018, 19(2), 485; https://doi.org/10.3390/ijms19020485

Integrins in T Cell Physiology

1
Department of Translational Medicine and Institute for Research and Cure of Autoimmune Diseases, University of Piemonte Orientale, 28100 Novara, Italy
2
Department of Translational Medicine, University of Eastern Piedmont, Novara—Italy and Oncology Division, University Hospital “Maggiore della Carità”, 28100 Novara, Italy
3
Department of Translational Medicine, University of Eastern Piedmont, Novara 28100—Italy and Palliative Care Division, A.S.L., 13100 Vercelli, Italy
*
Author to whom correspondence should be addressed.
Received: 24 December 2017 / Revised: 19 January 2018 / Accepted: 2 February 2018 / Published: 6 February 2018
(This article belongs to the Special Issue Integrins and Human Pathologies)
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Abstract

From the thymus to the peripheral lymph nodes, integrin-mediated interactions with neighbor cells and the extracellular matrix tune T cell behavior by organizing cytoskeletal remodeling and modulating receptor signaling. LFA-1 (αLβ2 integrin) and VLA-4 (α4β1 integrin) play a key role throughout the T cell lifecycle from thymocyte differentiation to lymphocyte extravasation and finally play a fundamental role in organizing immune synapse, providing an essential costimulatory signal for the T cell receptor. Apart from tuning T cell signaling, integrins also contribute to homing to specific target organs as exemplified by the importance of α4β7 in maintaining the gut immune system. However, apart from those well-characterized examples, the physiological significance of the other integrin dimers expressed by T cells is far less understood. Thus, integrin-mediated cell-to-cell and cell-to-matrix interactions during the T cell lifespan still represent an open field of research. View Full-Text
Keywords: adhesion; costimulation; signal 2; tension; cytoskeleton adhesion; costimulation; signal 2; tension; cytoskeleton
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bertoni, A.; Alabiso, O.; Galetto, A.S.; Baldanzi, G. Integrins in T Cell Physiology. Int. J. Mol. Sci. 2018, 19, 485.

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