Infectious Agents as Stimuli of Trained Innate Immunity
AbstractThe discoveries made over the past few years have modified the current immunological paradigm. It turns out that innate immunity cells can mount some kind of immunological memory, similar to that observed in the acquired immunity and corresponding to the defense mechanisms of lower organisms, which increases their resistance to reinfection. This phenomenon is termed trained innate immunity. It is based on epigenetic changes in innate immune cells (monocytes/macrophages, NK cells) after their stimulation with various infectious or non-infectious agents. Many infectious stimuli, including bacterial or fungal cells and their components (LPS, β-glucan, chitin) as well as viruses or even parasites are considered potent inducers of innate immune memory. Epigenetic cell reprogramming occurring at the heart of the phenomenon may provide a useful basis for designing novel prophylactic and therapeutic strategies to prevent and protect against multiple diseases. In this article, we present the current state of art on trained innate immunity occurring as a result of infectious agent induction. Additionally, we discuss the mechanisms of cell reprogramming and the implications for immune response stimulation/manipulation. View Full-Text
Share & Cite This Article
Rusek, P.; Wala, M.; Druszczyńska, M.; Fol, M. Infectious Agents as Stimuli of Trained Innate Immunity. Int. J. Mol. Sci. 2018, 19, 456.
Rusek P, Wala M, Druszczyńska M, Fol M. Infectious Agents as Stimuli of Trained Innate Immunity. International Journal of Molecular Sciences. 2018; 19(2):456.Chicago/Turabian Style
Rusek, Paulina; Wala, Mateusz; Druszczyńska, Magdalena; Fol, Marek. 2018. "Infectious Agents as Stimuli of Trained Innate Immunity." Int. J. Mol. Sci. 19, no. 2: 456.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.