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Int. J. Mol. Sci. 2018, 19(2), 451;

Common Variable Immunodeficiency and Gastric Malignancies

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine, University of Bari Medical School, 70124 Bari, Italy
Author to whom correspondence should be addressed.
Received: 21 December 2017 / Revised: 25 January 2018 / Accepted: 31 January 2018 / Published: 2 February 2018
(This article belongs to the Special Issue Molecular Features Distinguishing Gastric Cancer Subtypes)
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Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal manifestations and an increased risk of gastric carcinoma and lymphoma. This review discusses the latest advancements into the immunological, clinical and diagnostic aspects of gastric malignancies in patients with CVID. The exact molecular pathways underlying the relationships between CVID and gastric malignancies remain poorly understood. These include genetics, immune dysregulation and chronic infections by Helicobacter pylori. Further studies are needed to better stratify the risk for cancer in these patients, to elaborate surveillance programs aimed at preventing these complications, and to develop new and more effective therapeutic approaches. View Full-Text
Keywords: common variable immunodeficiency; gastric cancer; human immunoglobulins; lymphoproliferative disorders common variable immunodeficiency; gastric cancer; human immunoglobulins; lymphoproliferative disorders

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Leone, P.; Vacca, A.; Dammacco, F.; Racanelli, V. Common Variable Immunodeficiency and Gastric Malignancies. Int. J. Mol. Sci. 2018, 19, 451.

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