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Apoptosis: A Target for Anticancer Therapy

Department of Biology, Division of Natural and Social Sciences, Carthage College, Kenosha, WI 53140, USA
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Int. J. Mol. Sci. 2018, 19(2), 448; https://doi.org/10.3390/ijms19020448
Received: 21 November 2017 / Accepted: 14 December 2017 / Published: 2 February 2018
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
Apoptosis, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common anticancer therapy, chemotherapy. Promising new anticancer therapies are plant-derived compounds that exhibit anticancer activity through activating the apoptotic pathway. View Full-Text
Keywords: apoptosis; anticancer therapy; curcumin; apoptotic evasion apoptosis; anticancer therapy; curcumin; apoptotic evasion
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MDPI and ACS Style

Pfeffer, C.M.; Singh, A.T.K. Apoptosis: A Target for Anticancer Therapy. Int. J. Mol. Sci. 2018, 19, 448. https://doi.org/10.3390/ijms19020448

AMA Style

Pfeffer CM, Singh ATK. Apoptosis: A Target for Anticancer Therapy. International Journal of Molecular Sciences. 2018; 19(2):448. https://doi.org/10.3390/ijms19020448

Chicago/Turabian Style

Pfeffer, Claire M., and Amareshwar T.K. Singh. 2018. "Apoptosis: A Target for Anticancer Therapy" International Journal of Molecular Sciences 19, no. 2: 448. https://doi.org/10.3390/ijms19020448

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