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Review

Store-Operated Ca2+ Entry in Breast Cancer Cells: Remodeling and Functional Role

Department of Physiology, (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain
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Int. J. Mol. Sci. 2018, 19(12), 4053; https://doi.org/10.3390/ijms19124053
Received: 14 November 2018 / Revised: 3 December 2018 / Accepted: 11 December 2018 / Published: 14 December 2018
Breast cancer is the most common type of cancer in women. It is a heterogeneous disease that ranges from the less undifferentiated luminal A to the more aggressive basal or triple negative breast cancer molecular subtype. Ca2+ influx from the extracellular medium, but more specifically store-operated Ca2+ entry (SOCE), has been reported to play an important role in tumorigenesis and the maintenance of a variety of cancer hallmarks, including cell migration, proliferation, invasion or epithelial to mesenchymal transition. Breast cancer cells remodel the expression and functional role of the molecular components of SOCE. This review focuses on the functional role and remodeling of SOCE in breast cancer cells. The current studies suggest the need to deepen our understanding of SOCE in the biology of the different breast cancer subtypes in order to develop new and specific therapeutic strategies. View Full-Text
Keywords: STIM1; Orai1; TRPC channels; MCF7; MDA-MB-231; calcium entry; proliferation; migration; breast cancer STIM1; Orai1; TRPC channels; MCF7; MDA-MB-231; calcium entry; proliferation; migration; breast cancer
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MDPI and ACS Style

Jardin, I.; Lopez, J.J.; Salido, G.M.; Rosado, J.A. Store-Operated Ca2+ Entry in Breast Cancer Cells: Remodeling and Functional Role. Int. J. Mol. Sci. 2018, 19, 4053. https://doi.org/10.3390/ijms19124053

AMA Style

Jardin I, Lopez JJ, Salido GM, Rosado JA. Store-Operated Ca2+ Entry in Breast Cancer Cells: Remodeling and Functional Role. International Journal of Molecular Sciences. 2018; 19(12):4053. https://doi.org/10.3390/ijms19124053

Chicago/Turabian Style

Jardin, Isaac; Lopez, Jose J.; Salido, Gines M.; Rosado, Juan A. 2018. "Store-Operated Ca2+ Entry in Breast Cancer Cells: Remodeling and Functional Role" Int. J. Mol. Sci. 19, no. 12: 4053. https://doi.org/10.3390/ijms19124053

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