Preliminary Study of the Effect of Stereotactic Body Radiotherapy (SBRT) on the Immune System in Lung Cancer Patients Unfit for Surgery: Immunophenotyping Analysis
by
Arturo Navarro-Martín 1,*, Isabel Linares Galiana 1, Miguel A. Berenguer Frances 1, Jon Cacicedo 2, Rut Cañas Cortés 3, Silvia Comas Anton 4, Susana Padrones Sánchez 5, Santiago Bolívar Cuevas 6, Renate Parry 7
and Ferran Guedea Edo 1
Arturo Navarro-Martín 1,*, Isabel Linares Galiana 1, Miguel A. Berenguer Frances 1, Jon Cacicedo 2, Rut Cañas Cortés 3, Silvia Comas Anton 4, Susana Padrones Sánchez 5, Santiago Bolívar Cuevas 6, Renate Parry 7 and Ferran Guedea Edo 1
1
Radiation Oncology Department, Hospital Duran i Reynals, Institut Català d’Oncologia (ICO), Radiobiology and Cancer Group, ONCOBELL Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Avinguda de la Gran Via de l’Hospitalet 199-203, L’Hospitalet de Llobregat, 08098 Barcelona, Spain
2
Radiation Oncology Department, Hospital Universitario de Cruces, Plaza de Cruces s/n, E-48903 Barakaldo, Bizkaia, Spain
3
Radiobiology and Cancer Group, ONCOBELL Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Avinguda de la Gran Via de l’Hospitalet 199-203, L’Hospitalet de Llobregat, 08098 Barcelona, Spain
4
Radiation Oncology Department, Hospital Germans Trias i Pujol, 08098 Badalona, Spain
5
Respirology Department, Hospital Univesitari de Bellvitge, Hospitalet de Llobregat, Feixa Llarga s/n, E-08907 Barcelona, Spain
6
Radiology Department, Hospital Univesitari de Bellvitge, Hospitalet de Llobregat, Feixa Llarga s/n, E-08907 Barcelona, Spain
7
Senior Director, Global Translational Science, Varian Medical Systems, 3120 Hansen Way, Palo Alto, CA 94304, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 3963; https://doi.org/10.3390/ijms19123963
Received: 23 November 2018 / Revised: 5 December 2018 / Accepted: 6 December 2018 / Published: 9 December 2018
(This article belongs to the Special Issue Partnership of Radiotherapy and Immunotherapy)
An immunophenotyping analysis was performed in peripheral blood samples from seven patients with lung cancer unfit for surgery treated with stereotactic body radiotherapy (SBRT). The objective was to characterize the effect of SBRT on the host immune system. Four patients received 60 Gy (7.5 Gy × 8) and three 50 Gy (12.5 Gy × 4). Analyses were performed before SBRT, 72 h after SBRT, and at one, three, and six months after the end of SBRT. Of note, there was a specific increase of the immunoactive component of the immune system, with elevation of CD56+highCD16+ natural killer (NK) cells (0.95% at baseline to 1.38% at six months), and a decrease of the immunosuppressive component of the immune system, with decreases of CD4+CD25+Foxp3+CDA5RA− regulatory T cells (4.97% at baseline to 4.46% at six months), granulocytic myeloid-derived suppressor cells (G-MDSCs) (from 66.1% at baseline to 62.6% at six months) and monocytic (Mo-MDSCs) (8.2% at baseline to 6.2% at six months). These changes were already apparent at 72 h and persisted over six months. SBRT showed an effect on systemic immune cell populations, which is a relevant finding for supporting future combinations of SBRT with immunotherapy for treating lung cancer patients.
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Keywords:
stereotactic body radiotherapy (SBRT); immune system; immunomodulation; immunophenotyping; flow cytometry; non-small cell lung cancer; cytotoxic T lymphocytes; T helper lymphocytes; natural killer (NK) cells; regulatory T cells; myeloid-derived suppressor cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Navarro-Martín, A.; Galiana, I.L.; Berenguer Frances, M.A.; Cacicedo, J.; Cañas Cortés, R.; Comas Anton, S.; Padrones Sánchez, S.; Bolívar Cuevas, S.; Parry, R.; Guedea Edo, F. Preliminary Study of the Effect of Stereotactic Body Radiotherapy (SBRT) on the Immune System in Lung Cancer Patients Unfit for Surgery: Immunophenotyping Analysis. Int. J. Mol. Sci. 2018, 19, 3963.
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