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Int. J. Mol. Sci. 2018, 19(12), 3931; https://doi.org/10.3390/ijms19123931

Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer

1
Department of Biological Science, University of Bergen, 5008 Bergen, Norway
2
Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway
3
Department of Gynecology and Obstetrics, Haukeland University Hospital, 5053 Bergen, Norway
*
Author to whom correspondence should be addressed.
Received: 30 October 2018 / Revised: 26 November 2018 / Accepted: 3 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Molecular Research of Endometrial Pathophysiology)
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Abstract

The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally orchestrated by class I PI3K enzymes and negatively regulated by the phosphatase and tensin homologue, PTEN. Endometrial carcinomas harbour frequent alterations in components of the pathway, including changes in gene copy number and mutations, in particular in the oncogene PIK3CA, the gene encoding the PI3K catalytic subunit p110α, and the tumour suppressor PTEN. PIK3CB, encoding the other ubiquitously expressed class I isoform p110β, is less frequently altered but the few mutations identified to date are oncogenic. This isoform has received more research interest in recent years, particularly since PTEN-deficient tumours were found to be reliant on p110β activity to sustain transformation. In this review, we describe the current understanding of the common and distinct biochemical properties of the p110α and p110β isoforms, summarise their mutations and highlight how they are targeted in clinical trials in endometrial cancer. View Full-Text
Keywords: phosphoinositide 3-kinase; PIK3CA; PIK3CB; p110α; p110β; endometrial cancer phosphoinositide 3-kinase; PIK3CA; PIK3CB; p110α; p110β; endometrial cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mazloumi Gavgani, F.; Smith Arnesen, V.; Jacobsen, R.G.; Krakstad, C.; Hoivik, E.A.; Lewis, A.E. Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer. Int. J. Mol. Sci. 2018, 19, 3931.

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