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Int. J. Mol. Sci. 2018, 19(12), 3913; https://doi.org/10.3390/ijms19123913

Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects

1
Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8019, USA
2
Department of Biochemistry and Immunology, Federal University of Minas Gerais. Av. Antônio Carlos, 6627, Belo Horizonte—MG 31270-901, Brazil
*
Author to whom correspondence should be addressed.
Received: 22 October 2018 / Revised: 13 November 2018 / Accepted: 20 November 2018 / Published: 6 December 2018
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Abstract

Calcium (Ca2+) is a versatile second messenger that regulates a number of cellular processes in virtually every type of cell. The inositol 1,4,5-trisphosphate receptor (ITPR) is the only intracellular Ca2+ release channel in cholangiocytes, and is therefore responsible for Ca2+-mediated processes in these cells. This review will discuss the machinery responsible for Ca2+ signals in these cells, as well as experimental models used to investigate cholangiocyte Ca2+ signaling. We will also discuss the role of Ca2+ in the normal and abnormal regulation of secretion and apoptosis in cholangiocytes, two of the best characterized processes mediated by Ca2+ in this cell type. View Full-Text
Keywords: Ca2+; inositol 1,4,5-trisphosphate (InsP3); inositol 1,4,5-trisphosphate receptors (ITPRs); cholangiocytes; biliary tree; secretion Ca2+; inositol 1,4,5-trisphosphate (InsP3); inositol 1,4,5-trisphosphate receptors (ITPRs); cholangiocytes; biliary tree; secretion
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Rodrigues, M.A.; Gomes, D.A.; Nathanson, M.H. Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects. Int. J. Mol. Sci. 2018, 19, 3913.

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