Next Article in Journal
Melatonin May Increase Anticancer Potential of Pleiotropic Drugs
Next Article in Special Issue
The Circadian tau Mutation in Casein Kinase 1 Is Part of a Larger Domain That Can Be Mutated to Shorten Circadian Period
Previous Article in Journal
A Complex Relationship between Visfatin and Resistin and microRNA: An In Vitro Study on Human Chondrocyte Cultures
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(12), 3911; https://doi.org/10.3390/ijms19123911

Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back

1
Department of Biology, University of Padova, 35131 Padova, Italy
2
Cognitive Neuroscience Center, University of Padova, 35100 Padova, Italy
*
Authors to whom correspondence should be addressed.
Received: 18 October 2018 / Revised: 23 November 2018 / Accepted: 30 November 2018 / Published: 6 December 2018
(This article belongs to the Special Issue Genetic and Molecular Bases of the Circadian Rhythms)
Full-Text   |   PDF [1156 KB, uploaded 6 December 2018]   |  

Abstract

Clinical and research studies have suggested a link between Parkinson’s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD. Apart from the conservation of many genes, cellular mechanisms, signaling pathways, and neuronal processes, Drosophila shows an organized central nervous system and well-characterized complex behavioral phenotypes. In fact, Drosophila has been successfully used in the dissection of the circadian system and as a model for neurodegenerative disorders, including PD. Here, we describe the fly circadian and dopaminergic systems and report recent studies which indicate the presence of circadian abnormalities in some fly PD genetic models. We discuss the use of Drosophila to investigate whether, in adults, the disruption of the circadian system might be causative of brain neurodegeneration. We also consider approaches using Drosophila, which might provide new information on the link between PD and the circadian clock. As a corollary, since PD develops its symptomatology over a large part of the organism’s lifespan and given the relatively short lifespan of fruit flies, we suggest that genetic models of PD could be used to perform lifelong screens for drug-modulators of general and/or circadian-related PD traits. View Full-Text
Keywords: Parkison’s disease; Drosophila; circadian clock; dopaminergic system; PD models; dj-1 Parkison’s disease; Drosophila; circadian clock; dopaminergic system; PD models; dj-1
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

De Lazzari, F.; Bisaglia, M.; Zordan, M.A.; Sandrelli, F. Circadian Rhythm Abnormalities in Parkinson’s Disease from Humans to Flies and Back. Int. J. Mol. Sci. 2018, 19, 3911.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top