Next Article in Journal
Coarse-Grained Protein Dynamics Studies Using Elastic Network Models
Next Article in Special Issue
Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study
Previous Article in Journal
Comparative Proteomic Analysis Reveals Elevated Capacity for Photosynthesis in Polyphenol Oxidase Expression-Silenced Clematis terniflora DC. Leaves
Previous Article in Special Issue
Boldine Improves Kidney Damage in the Goldblatt 2K1C Model Avoiding the Increase in TGF-β
Open AccessReview

An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers

1
Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania
2
Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, University Transilvania Braşov, 500019 Brasov, Romania
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 3898; https://doi.org/10.3390/ijms19123898
Received: 18 November 2018 / Revised: 2 December 2018 / Accepted: 3 December 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Nutraceuticals in Cancer and Disease Prevention)
In recent years, a wide range of studies have pointed out the importance of nutraceuticals as reservoirs of therapeutic compounds for several diseases, including cancer. This study is centered on the role of some nutraceuticals as anticancer agents and on their efficiency in the oncological gynecological field. Gynecological cancers include cervical, ovarian, and breast neoplasia and these are the major causes of morbidity and mortality in the female population. Cervical neoplasia affects sexually active women aged between 30 and 40 years and is considered the second leading cause of death for women worldwide. Epidemiological studies have shown a strong association of this cancer with human papilloma virus (HPV) infection, independent of any others risk factors. Ovarian cancer represents about 4% of all women’s cancers and breast neoplasia registers 52.8 new cases per 100,000 women annually. Since ancient times, herbal therapies have shown a wide range of beneficial effects and a high potential for safeguarding human health. Azadirachta indica (Neem) is a medicinal plant of Indian origin, a tree with more of 140 isolated compounds and at least 35 biologically active principles that have shown an important influence as tumor suppressors by interfering with the carcinogenesis process. Used for centuries in Asia as a natural remedy for cancer, neem compounds present in bark, leaves, flowers, and seed oil have been shown to possess properties such as chemopreventive capacity, apoptotic activities, immunomodulatory effects, and induction of p53-independent apoptosis. The current study is a systematic literature review based on the anticarcinogenic potential of neem compounds in gynecological cancers. View Full-Text
Keywords: Azadirachta indica; carcinogenesis; cervical cancer; ovarian cancer; breast cancer Azadirachta indica; carcinogenesis; cervical cancer; ovarian cancer; breast cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Moga, M.A.; Bălan, A.; Anastasiu, C.V.; Dimienescu, O.G.; Neculoiu, C.D.; Gavriș, C. An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers. Int. J. Mol. Sci. 2018, 19, 3898.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop