PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

Sánchez-Alegría, Karina; Flores-León, Manuel; Avila-Muñoz, Evangelina; Rodríguez-Corona, Nelly; Arias, Clorinda

doi:10.3390/ijms19123725

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PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

by

Karina Sánchez-Alegría

^†,

Manuel Flores-León

^†

,

Evangelina Avila-Muñoz

,

Nelly Rodríguez-Corona

and

Clorinda Arias

^*

Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70-228, 04510 México, DF, Mexico

^*

Author to whom correspondence should be addressed.

^†

These two authors contributed equally to this work.

Int. J. Mol. Sci. 2018, 19(12), 3725; https://doi.org/10.3390/ijms19123725

Submission received: 19 October 2018 / Revised: 13 November 2018 / Accepted: 15 November 2018 / Published: 23 November 2018

(This article belongs to the Special Issue Signaling Promiscuity of PI3K)

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Abstract

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. Less is known regarding its critical role in neuronal physiology, neuronal metabolism, tissue homeostasis, and the control of gene expression in the central nervous system in healthy and diseased states. The aim of the present work is to review cumulative evidence regarding the participation of PI3K pathways in neuronal function, focusing on their role in neuronal metabolism and transcriptional regulation of genes involved in neuronal maintenance and plasticity or on the expression of pathological hallmarks associated with neurodegeneration.

Keywords: PI3K signaling; neurodegeneration; neuronal metabolism; gene expression; neuroinflammation

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Sánchez-Alegría, K.; Flores-León, M.; Avila-Muñoz, E.; Rodríguez-Corona, N.; Arias, C. PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. Int. J. Mol. Sci. 2018, 19, 3725. https://doi.org/10.3390/ijms19123725

AMA Style

Sánchez-Alegría K, Flores-León M, Avila-Muñoz E, Rodríguez-Corona N, Arias C. PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. International Journal of Molecular Sciences. 2018; 19(12):3725. https://doi.org/10.3390/ijms19123725

Chicago/Turabian Style

Sánchez-Alegría, Karina, Manuel Flores-León, Evangelina Avila-Muñoz, Nelly Rodríguez-Corona, and Clorinda Arias. 2018. "PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions" International Journal of Molecular Sciences 19, no. 12: 3725. https://doi.org/10.3390/ijms19123725

APA Style

Sánchez-Alegría, K., Flores-León, M., Avila-Muñoz, E., Rodríguez-Corona, N., & Arias, C. (2018). PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. International Journal of Molecular Sciences, 19(12), 3725. https://doi.org/10.3390/ijms19123725

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PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

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