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Open AccessArticle

Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

1
Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea
2
Department of Electrical Engineering, Gachon University, Seongnam 13120, Korea
3
Industrial Technology Convergence Center, Pohang Accelerator Laboratory, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Korea
4
Advanced Bio Convergence Center, Pohang Technopark, Pohang 37668, Korea
5
Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu 41940, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(11), 3640; https://doi.org/10.3390/ijms19113640
Received: 12 October 2018 / Revised: 30 October 2018 / Accepted: 16 November 2018 / Published: 19 November 2018
(This article belongs to the Special Issue Head Tissues Regeneration)
The regeneration of bone defects caused by periodontal disease or trauma is an important goal. Porous hydroxyapatite (HA) is an osteoconductive graft material. However, the hydrophobic properties of HA can be a disadvantage in the initial healing process. HA can be coated with TiO2 to improve its hydrophilicity, and ultraviolet irradiation (UV) can further increase the hydrophilicity by photofunctionalization. This study was designed to evaluate the effect of 5% TiO2-coated HA on rabbit calvarial defects and compare it with that of photofunctionalization on new bone in the early stage. The following four study groups were established, negative control, HA, TiO2-coated HA, and TiO2-coated HA with UV. The animals were sacrificed and the defects were assessed by radiography as well as histologic and histomorphometric analyses. At 2 and 8 weeks postoperatively, the TiO2-coated HA with UV group and TiO2-coated HA group showed significantly higher percentages of new bone than the control group (p < 0.05). UV irradiation increased the extent of new bone formation, and there was a significant difference between the TiO2-coated HA group and TiO2-coated HA with UV group. The combination of TiO2/HA and UV irradiation in bone regeneration appears to induce a favorable response. View Full-Text
Keywords: regeneration; calvarial defect; photofunctionalization; ultraviolet; titanium dioxide; hydrophilicity regeneration; calvarial defect; photofunctionalization; ultraviolet; titanium dioxide; hydrophilicity
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Lee, J.-E.; Bark, C.W.; Quy, H.V.; Seo, S.-J.; Lim, J.-H.; Kang, S.-A.; Lee, Y.; Lee, J.-M.; Suh, J.-Y.; Kim, Y.-G. Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects. Int. J. Mol. Sci. 2018, 19, 3640.

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