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The Antitumor Natural Compound Falcarindiol Disrupts Neural Stem Cell Homeostasis by Suppressing Notch Pathway

1
Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea
2
National Development Institute of Korean Medicine, Gyeongsan, Gyeongsangbuk-do 38540, Korea
3
Department of Cosmetic Science and Technology, College of Bio-industry, Daegu Haany University, Gyeongsan 38610, Korea
4
Department of Pharmacology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, Daegu 41940, Korea
*
Authors to whom correspondence should be addressed.
Both authors contributed equally.
Int. J. Mol. Sci. 2018, 19(11), 3432; https://doi.org/10.3390/ijms19113432
Received: 4 October 2018 / Revised: 25 October 2018 / Accepted: 31 October 2018 / Published: 1 November 2018
(This article belongs to the Section Biochemistry)
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Abstract

Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional neurons and glial cells. The disruption in NSC homeostasis and/or the impaired neurogenesis lead to diverse neurological diseases, including depression, dementia, and neurodegenerative disorders. Falcarindiol (FAD) is a polyacetylene found in many plants, and FAD shows the cytotoxicity against breast cancers and colon cancers. However, there is no research on the consequence of FAD treatment in normal stem cells. Here, we suggest that FAD has anticancer roles against glioblastoma cells by inducing the differentiation of glioblastoma stem-like cells, as well as activating apoptosis pathway in glioblastoma cells. On the other hand, we also show that FAD has detrimental effects by disrupting the maintenance of normal NSCs and altering the balance between self-renewal and differentiation of NSCs. View Full-Text
Keywords: falcarindiol; neural stem cell; Notch pathway; apoptosis; differentiation falcarindiol; neural stem cell; Notch pathway; apoptosis; differentiation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kim, T.-J.; Kwon, H.-S.; Kang, M.; Leem, H.H.; Lee, K.-H.; Kim, D.-Y. The Antitumor Natural Compound Falcarindiol Disrupts Neural Stem Cell Homeostasis by Suppressing Notch Pathway. Int. J. Mol. Sci. 2018, 19, 3432.

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