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Int. J. Mol. Sci. 2018, 19(10), 3143;

Current Trends of Microfluidic Single-Cell Technologies

Department of Engineering Design, Indian Institute of Technology Madras, Tamil Nadu 600036, India
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
Department of Engineering and System Science, National Tsing Hua University, Hsinchu City 30071, Taiwan
Department of Medical Science, National Tsing Hua University, Hsinchu City 30071, Taiwan
Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 6 July 2018 / Revised: 27 September 2018 / Accepted: 27 September 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Single Cell Technology)


The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in single-cell technologies and their applications in single-cell manipulation, diagnosis, and therapeutics development. View Full-Text
Keywords: single-cell; lab-on-a-chip; microfluidics Bio-MEMS; manipulation; diagnosis; therapeutics; drug delivery single-cell; lab-on-a-chip; microfluidics Bio-MEMS; manipulation; diagnosis; therapeutics; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Shinde, P.; Mohan, L.; Kumar, A.; Dey, K.; Maddi, A.; Patananan, A.N.; Tseng, F.-G.; Chang, H.-Y.; Nagai, M.; Santra, T.S. Current Trends of Microfluidic Single-Cell Technologies. Int. J. Mol. Sci. 2018, 19, 3143.

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