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Review

Current Trends of Microfluidic Single-Cell Technologies

1
Department of Engineering Design, Indian Institute of Technology Madras, Tamil Nadu 600036, India
2
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
3
Department of Engineering and System Science, National Tsing Hua University, Hsinchu City 30071, Taiwan
4
Department of Medical Science, National Tsing Hua University, Hsinchu City 30071, Taiwan
5
Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(10), 3143; https://doi.org/10.3390/ijms19103143
Received: 6 July 2018 / Revised: 27 September 2018 / Accepted: 27 September 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Single Cell Technology)
The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in single-cell technologies and their applications in single-cell manipulation, diagnosis, and therapeutics development. View Full-Text
Keywords: single-cell; lab-on-a-chip; microfluidics Bio-MEMS; manipulation; diagnosis; therapeutics; drug delivery single-cell; lab-on-a-chip; microfluidics Bio-MEMS; manipulation; diagnosis; therapeutics; drug delivery
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MDPI and ACS Style

Shinde, P.; Mohan, L.; Kumar, A.; Dey, K.; Maddi, A.; Patananan, A.N.; Tseng, F.-G.; Chang, H.-Y.; Nagai, M.; Santra, T.S. Current Trends of Microfluidic Single-Cell Technologies. Int. J. Mol. Sci. 2018, 19, 3143. https://doi.org/10.3390/ijms19103143

AMA Style

Shinde P, Mohan L, Kumar A, Dey K, Maddi A, Patananan AN, Tseng F-G, Chang H-Y, Nagai M, Santra TS. Current Trends of Microfluidic Single-Cell Technologies. International Journal of Molecular Sciences. 2018; 19(10):3143. https://doi.org/10.3390/ijms19103143

Chicago/Turabian Style

Shinde, Pallavi, Loganathan Mohan, Amogh Kumar, Koyel Dey, Anjali Maddi, Alexander N. Patananan, Fan-Gang Tseng, Hwan-You Chang, Moeto Nagai, and Tuhin S. Santra 2018. "Current Trends of Microfluidic Single-Cell Technologies" International Journal of Molecular Sciences 19, no. 10: 3143. https://doi.org/10.3390/ijms19103143

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