Relevance of MicroRNAs as Potential Diagnostic and Prognostic Markers in Colorectal Cancer
Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia in Katowice, St. Medyków 18, 40-752 Katowice, Poland
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Int. J. Mol. Sci. 2018, 19(10), 2944; https://doi.org/10.3390/ijms19102944
Received: 3 July 2018
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Revised: 21 September 2018
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Accepted: 25 September 2018
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Published: 27 September 2018
(This article belongs to the Special Issue MicroRNA as Biomarkers in Cancer Diagnostics and Therapy)
Colorectal cancer (CRC) is currently the third and the second most common cancer in men and in women, respectively. Every year, more than one million new CRC cases and more than half a million deaths are reported worldwide. The majority of new cases occur in developed countries. Current screening methods have significant limitations. Therefore, a lot of scientific effort is put into the development of new diagnostic biomarkers of CRC. Currently used prognostic markers are also limited in assessing the effectiveness of CRC therapy. MicroRNAs (miRNAs) are a promising subject of research especially since single miRNA can recognize a variety of different mRNA transcripts. MiRNAs have important roles in epigenetic regulation of basic cellular processes, such as proliferation, apoptosis, differentiation, and migration, and may serve as potential oncogenes or tumor suppressors during cancer development. Indeed, in a large variety of human tumors, including CRC, significant distortions in miRNA expression profiles have been observed. Thus, the use of miRNAs as diagnostic and prognostic biomarkers in cancer, particularly in CRC, appears to be an inevitable consequence of the advancement in oncology and gastroenterology. Here, we review the literature to discuss the potential usefulness of selected miRNAs as diagnostic and prognostic biomarkers in CRC.
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Keywords:
colorectal; cancer; microRNA; biomarkers
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MDPI and ACS Style
Hibner, G.; Kimsa-Furdzik, M.; Francuz, T. Relevance of MicroRNAs as Potential Diagnostic and Prognostic Markers in Colorectal Cancer. Int. J. Mol. Sci. 2018, 19, 2944. https://doi.org/10.3390/ijms19102944
AMA Style
Hibner G, Kimsa-Furdzik M, Francuz T. Relevance of MicroRNAs as Potential Diagnostic and Prognostic Markers in Colorectal Cancer. International Journal of Molecular Sciences. 2018; 19(10):2944. https://doi.org/10.3390/ijms19102944
Chicago/Turabian StyleHibner, Grzegorz, Małgorzata Kimsa-Furdzik, and Tomasz Francuz. 2018. "Relevance of MicroRNAs as Potential Diagnostic and Prognostic Markers in Colorectal Cancer" International Journal of Molecular Sciences 19, no. 10: 2944. https://doi.org/10.3390/ijms19102944
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