G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
Abstract
:1. Introduction
2. Aging, Metabolic Functionality, DNA Stability, Damage and Repair
2.1. Metabolic Dysfunction, Oxidative Damage and Aging
2.2. Oxidative Aging and DNA Damage Responses
2.3. Metabolic-Clock Process Linked with DDR
3. G Protein-Coupled Receptor Systems: Intersections with DNA Damage and Repair Processes
3.1. GPCR Signaling Diversity
3.2. GPCR Functionality in the Context of Molecular Gerontology
3.3. GPCR Signaling Systems and DNA Damage Repair
3.3.1. Heptahelical GPCRs and DNA Damage
Lysophosphatidic Acid Receptor
Dopamine D2 Receptor
CXCR4 Receptor
Hydroxycarboxylic Acid (Lactate) Receptor
Melanocortin 1 Receptor
Angiotensin II Receptor
3.3.2. β-Arrestin Family Proteins
3.3.3. G Protein-Coupled Receptor Kinases and Associated Proteins
3.3.4. Regulator of G Protein Signaling Proteins
3.3.5. Non-Canonical GPCR-Interacting Proteins
Regulated in Development and DNA Damage Responses
Fanconi Anemia A Protein
Poly(ADP-ribose) Polymerase 1 Protein
Angiotensin II Type 2 Receptor-Interacting Protein
4. The GPCR-DDR Signaling Intersection and Its Potential Therapeutic Exploitation
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Leysen, H.; Van Gastel, J.; Hendrickx, J.O.; Santos-Otte, P.; Martin, B.; Maudsley, S. G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes. Int. J. Mol. Sci. 2018, 19, 2919. https://doi.org/10.3390/ijms19102919
Leysen H, Van Gastel J, Hendrickx JO, Santos-Otte P, Martin B, Maudsley S. G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes. International Journal of Molecular Sciences. 2018; 19(10):2919. https://doi.org/10.3390/ijms19102919
Chicago/Turabian StyleLeysen, Hanne, Jaana Van Gastel, Jhana O. Hendrickx, Paula Santos-Otte, Bronwen Martin, and Stuart Maudsley. 2018. "G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes" International Journal of Molecular Sciences 19, no. 10: 2919. https://doi.org/10.3390/ijms19102919