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Int. J. Mol. Sci. 2018, 19(1), 75; https://doi.org/10.3390/ijms19010075

Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment

1
School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan
2
PhD Program in Medicine Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan
Received: 11 December 2017 / Revised: 22 December 2017 / Accepted: 24 December 2017 / Published: 28 December 2017
(This article belongs to the Special Issue Targeting Cancer through RNA Biology)
Full-Text   |   PDF [225 KB, uploaded 28 December 2017]

Abstract

A growing body of studies has documented the pathological influence of impaired alternative splicing (AS) events on numerous diseases, including cancer. In addition, the generation of alternatively spliced isoforms is frequently noted to result in drug resistance in many cancer therapies. To gain comprehensive insights into the impacts of AS events on cancer biology and therapeutic developments, this paper highlights recent findings regarding the therapeutic routes of targeting alternative-spliced isoforms and splicing regulators to treatment strategies for distinct cancers. View Full-Text
Keywords: alternative splicing; oligonucleotide; small molecule alternative splicing; oligonucleotide; small molecule
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lin, J.-C. Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment. Int. J. Mol. Sci. 2018, 19, 75.

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