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Int. J. Mol. Sci. 2018, 19(1), 18; https://doi.org/10.3390/ijms19010018

The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine

Department of Pharmacology and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands
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Received: 6 November 2017 / Revised: 8 December 2017 / Accepted: 19 December 2017 / Published: 21 December 2017
(This article belongs to the Special Issue Traditional Medicine – Unraveling Its Molecular Mechanism)
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Abstract

Many Western drugs can give rise to serious side effects due to their ability to bind to acetylcholine receptors in the brain. This aggravates when they are combined, which is known as anticholinergic accumulation (AA). Some bioactives in Traditional Chinese Medicine (TCM) are known to block acetylcholine receptors and thus potentially cause AA. The AA of TCM was screened by quantifying the displacement of [3H] pirenzepine on acetylcholine receptors in a rat brain homogenate. We used a new unit to express AA, namely the Total Atropine Equivalents (TOAT). The TOAT of various herbs used in TCM was very diverse and even negative for some herbs. This is indicative for the broadness of the pallet of ingredients used in TCM. Three TCM formulas were screened for AA: Ma Huang Decotion (MHD), Antiasthma Simplified Herbal Medicine intervention (ASHMI), and Yu Ping Feng San (YPFS). The TOAT of ASHMI was indicative for an additive effect of herbs used in it. Nevertheless, it can be calculated that one dose of ASHMI is probably too low to cause AA. The TOAT of YPFS was practically zero. This points to a protective interaction of AA. Remarkably, MHD gave a negative TOAT, indicating that the binding to the acetylcholine receptors was increased, which also circumvents AA. In conclusion, our results indicate that TCM is not prone to give AA and support that there is an intricate interaction between the various bioactives in TCM to cure diseases with minimal side effects. View Full-Text
Keywords: Traditional Chinese Medicine; anticholinergic accumulation; Total Atropine Equivalents Traditional Chinese Medicine; anticholinergic accumulation; Total Atropine Equivalents
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Zhang, M.; Vrolijk, M.; Haenen, G.R.M.M. The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine. Int. J. Mol. Sci. 2018, 19, 18.

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