Fungi in Bronchiectasis: A Concise Review
AbstractAlthough the spectrum of fungal pathology has been studied extensively in immunosuppressed patients, little is known about the epidemiology, risk factors, and management of fungal infections in chronic pulmonary diseases like bronchiectasis. In bronchiectasis patients, deteriorated mucociliary clearance—generally due to prior colonization by bacterial pathogens—and thick mucosity propitiate, the persistence of fungal spores in the respiratory tract. The most prevalent fungi in these patients are Candida albicans and Aspergillus fumigatus; these are almost always isolated with bacterial pathogens like Haemophillus influenzae and Pseudomonas aeruginosa, making very difficult to define their clinical significance. Analysis of the mycobiome enables us to detect a greater diversity of microorganisms than with conventional cultures. The results have shown a reduced fungal diversity in most chronic respiratory diseases, and that this finding correlates with poorer lung function. Increased knowledge of both the mycobiome and the complex interactions between the fungal, viral, and bacterial microbiota, including mycobacteria, will further our understanding of the mycobiome’s relationship with the pathogeny of bronchiectasis and the development of innovative therapies to combat it. View Full-Text
A printed edition of this Special Issue is available here.
Share & Cite This Article
Máiz, L.; Nieto, R.; Cantón, R.; Gómez G. de la Pedrosa, E.; Martinez-García, M.Á. Fungi in Bronchiectasis: A Concise Review. Int. J. Mol. Sci. 2018, 19, 142.
Máiz L, Nieto R, Cantón R, Gómez G. de la Pedrosa E, Martinez-García MÁ. Fungi in Bronchiectasis: A Concise Review. International Journal of Molecular Sciences. 2018; 19(1):142.Chicago/Turabian Style
Máiz, Luis; Nieto, Rosa; Cantón, Rafael; Gómez G. de la Pedrosa, Elia; Martinez-García, Miguel Á. 2018. "Fungi in Bronchiectasis: A Concise Review." Int. J. Mol. Sci. 19, no. 1: 142.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.