Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides
Abstract
:1. Introduction
2. The Genetic Architecture of MDD and SCZ
3. Early Life Events Preset Adult Behavior
4. From Epigenetics to Epigenomics
5. Early Life Adversity-Dependent Epigenomic Responses as Risk Factor for MDD
6. Epigenomics in SCZ
6.1. Epigenomic Changes in SCZ Are Enriched at Neurodevelopmental Loci
6.2. Epigenomic Changes in SCZ Are Genetically Controlled
6.3. A Role for Fetal meQTLs in Mediating the Genetic Risk for SCZ
7. Conclusions and Outlook
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Hoffmann, A.; Sportelli, V.; Ziller, M.; Spengler, D. Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides. Int. J. Mol. Sci. 2017, 18, 1711. https://doi.org/10.3390/ijms18081711
Hoffmann A, Sportelli V, Ziller M, Spengler D. Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides. International Journal of Molecular Sciences. 2017; 18(8):1711. https://doi.org/10.3390/ijms18081711
Chicago/Turabian StyleHoffmann, Anke, Vincenza Sportelli, Michael Ziller, and Dietmar Spengler. 2017. "Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides" International Journal of Molecular Sciences 18, no. 8: 1711. https://doi.org/10.3390/ijms18081711