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Mechanosensitive miRNAs and Bone Formation

by Zhihao Chen 1,2,3, Yan Zhang 1,2,3, Chao Liang 2,4, Lei Chen 1,2,3, Ge Zhang 2,4,* and Airong Qian 1,2,3,*
Laboratory for Bone Metabolism, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
NPU-HKBU Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Northwestern Polytechnical University, Xi’an 710072, China
Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen 518057, China
Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(8), 1684;
Received: 8 June 2017 / Revised: 25 July 2017 / Accepted: 28 July 2017 / Published: 2 August 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
Mechanical stimuli are required for the maintenance of skeletal integrity and bone mass. An increasing amount of evidence indicates that multiple regulators (e.g., hormone, cytoskeleton proteins and signaling pathways) are involved in the mechanical stimuli modulating the activities of osteogenic cells and the process of bone formation. Significantly, recent studies have showed that several microRNAs (miRNAs) were sensitive to various mechanical stimuli and played a crucial role in osteogenic differentiation and bone formation. However, the functional roles and further mechanisms of mechanosensitive miRNAs in bone formation are not yet completely understood. This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli. View Full-Text
Keywords: mechanical stimuli; mechanosensitive miRNAs; bone formation; osteogenic differentiation mechanical stimuli; mechanosensitive miRNAs; bone formation; osteogenic differentiation
MDPI and ACS Style

Chen, Z.; Zhang, Y.; Liang, C.; Chen, L.; Zhang, G.; Qian, A. Mechanosensitive miRNAs and Bone Formation. Int. J. Mol. Sci. 2017, 18, 1684.

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