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Review

The Role of Ghrelin and Ghrelin Signaling in Aging

1
Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890-8544, Japan
2
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
3
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(7), 1511; https://doi.org/10.3390/ijms18071511
Received: 22 June 2017 / Revised: 4 July 2017 / Accepted: 7 July 2017 / Published: 12 July 2017
(This article belongs to the Special Issue Neurobiological Perspectives on Ghrelin)
With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism. View Full-Text
Keywords: ghrelin; calorie restriction; longevity; ghrelin resistance; ghrelin agonist ghrelin; calorie restriction; longevity; ghrelin resistance; ghrelin agonist
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MDPI and ACS Style

Amitani, M.; Amitani, H.; Cheng, K.-C.; Kairupan, T.S.; Sameshima, N.; Shimoshikiryo, I.; Mizuma, K.; Rokot, N.T.; Nerome, Y.; Owaki, T.; Asakawa, A.; Inui, A. The Role of Ghrelin and Ghrelin Signaling in Aging. Int. J. Mol. Sci. 2017, 18, 1511. https://doi.org/10.3390/ijms18071511

AMA Style

Amitani M, Amitani H, Cheng K-C, Kairupan TS, Sameshima N, Shimoshikiryo I, Mizuma K, Rokot NT, Nerome Y, Owaki T, Asakawa A, Inui A. The Role of Ghrelin and Ghrelin Signaling in Aging. International Journal of Molecular Sciences. 2017; 18(7):1511. https://doi.org/10.3390/ijms18071511

Chicago/Turabian Style

Amitani, Marie, Haruka Amitani, Kai-Chun Cheng, Timothy Sean Kairupan, Nanami Sameshima, Ippei Shimoshikiryo, Kimiko Mizuma, Natasya Trivena Rokot, Yasuhito Nerome, Tetsuhiro Owaki, Akihiro Asakawa, and Akio Inui. 2017. "The Role of Ghrelin and Ghrelin Signaling in Aging" International Journal of Molecular Sciences 18, no. 7: 1511. https://doi.org/10.3390/ijms18071511

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