Microbiota, Inflammation and Colorectal Cancer
AbstractColorectal cancer, the fourth leading cause of cancer-related death worldwide, is a multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition, increased evidence has established a role for the intestinal microbiota in the development of colorectal cancer. Indeed, changes in the intestinal microbiota composition in colorectal cancer patients compared to control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. This review will summarize the current knowledge about the potential links between the intestinal microbiota and colorectal cancer, with a focus on the pro-carcinogenic properties of bacterial microbiota such as induction of inflammation, the biosynthesis of genotoxins that interfere with cell cycle regulation and the production of toxic metabolites. Finally, we will describe the potential therapeutic strategies based on intestinal microbiota manipulation for colorectal cancer treatment. View Full-Text
A printed edition of this Special Issue is available here.
Share & Cite This Article
Lucas, C.; Barnich, N.; Nguyen, H.T.T. Microbiota, Inflammation and Colorectal Cancer. Int. J. Mol. Sci. 2017, 18, 1310.
Lucas C, Barnich N, Nguyen HTT. Microbiota, Inflammation and Colorectal Cancer. International Journal of Molecular Sciences. 2017; 18(6):1310.Chicago/Turabian Style
Lucas, Cécily; Barnich, Nicolas; Nguyen, Hang T.T. 2017. "Microbiota, Inflammation and Colorectal Cancer." Int. J. Mol. Sci. 18, no. 6: 1310.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.