Local Actions of Melatonin in Somatic Cells of the Testis
Abstract
:1. Introduction
2. Melatonin in Leydig Cells
3. Melatonin in Sertoli Cells
4. Melatonin in Testicular Immune Cells
5. Conclusions
Acknowledgments
Conflicts of Interest
References
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Cell Types | Species/Cell Lines | Melotonin Effects | Receptor Types | Melatonin Concentrations | References | |
---|---|---|---|---|---|---|
Leydig cell | mouse | Inhibition of steroid production | Inhibition of StAR protein expression | Mt1 and/or Mt2 | 10 nM to 1 µM | [21] |
MA-10 | Inhibition of progesterone production | Mt1 and/or Mt2 | 10 nM to 1 µM | [21] | ||
Rat | Inhibition of steroid production | Inhibition of androgen production | - | 4 pM to 4 µM | [40] | |
Inhibition of GnRH-dependent intracellular Ca2+release | - | 0.2 pM | [46] | |||
Hamster | Inhibition of steroid production | Stimulation of CRH production | Mt1 | 1 and 10 µM | [12,54] | |
Stimulation of tyrosine phosphatases activity | Mt1 | 1 and 10 µM | [54] | |||
Inhibition of erk and jnk phosphorylation | Mt1 | 1 and 10 µM | [54] | |||
Downregulation of c-fos and c-jun expression | Mt1 | 1 and 10 µM | [54] | |||
Inhibition of StAR, Hsd3b and Hsd17b3 expression | Mt1 | 1 and 10 µM | [12,54] | |||
Inhibition of cAMP generation | Mt1 | 1 µM | [12] | |||
Inhibition of androgen production | Mt1 | 100 pM to 1 µM | [12,54] | |||
Sertoli cell | Rat | Regulation of energy metabolism | Inhibition of basal lactate production | Mt1 and Mt2 | 1 mM | [33] |
Upregulation of the insulin-stimulated lactate generation | Mt1 and Mt2 | 1 mM | [33] | |||
Stimulation of GLUT1 protein expression and glucose consumption | 1 mM | [33] | ||||
Inhibition of LDH protein expression and activity | Mt1 and Mt2 | 1 mM | [33] | |||
Stimulation of acetate production | 1 mM | [33] | ||||
Prevention of testicular damage | Regulation of intracellular redox state | Mt1 and Mt2 | 1 mM | [33] | ||
Hamster | Prevention of testicular damage | Stimulation of the responsiveness to FSH during testicular development | - | 25 µg daily injection (1 to 15 wk) | [24] | |
Bovine | Stimulation of cell growth/proliferation | Downregulation of mRNA P21 expression | Mt1 and Mt2 | 0.3 to 1 nM | [59] | |
Regulation of spermatogenesis | Upregulation of Cyclin D1, Cyclin E, Pdgfa, Dhh, Ocludin and Claudin expression | Mt1 and Mt2 | 0.3 to 1 nM | [59] | ||
Goat | Stimulation of SSCs proliferation | Stimulation of GDNF production | Mt1 and Mt2 | 1 nM and 1 µM | [73] |
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Frungieri, M.B.; Calandra, R.S.; Rossi, S.P. Local Actions of Melatonin in Somatic Cells of the Testis. Int. J. Mol. Sci. 2017, 18, 1170. https://doi.org/10.3390/ijms18061170
Frungieri MB, Calandra RS, Rossi SP. Local Actions of Melatonin in Somatic Cells of the Testis. International Journal of Molecular Sciences. 2017; 18(6):1170. https://doi.org/10.3390/ijms18061170
Chicago/Turabian StyleFrungieri, Mónica Beatriz, Ricardo Saúl Calandra, and Soledad Paola Rossi. 2017. "Local Actions of Melatonin in Somatic Cells of the Testis" International Journal of Molecular Sciences 18, no. 6: 1170. https://doi.org/10.3390/ijms18061170