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Human Chorionic Gonadotropin: The Pregnancy Hormone and More

IVF Unit, 1st Department of Obstetrics & Gynecology, National & Kapodistrian University of Athens, Alexandra Hospital, 11528 Athens, Greece
Author to whom correspondence should be addressed.
Academic Editor: Udo Jeschke
Int. J. Mol. Sci. 2017, 18(5), 1059;
Received: 26 February 2017 / Revised: 3 May 2017 / Accepted: 10 May 2017 / Published: 14 May 2017
(This article belongs to the Special Issue hCG—An Endocrine, Regulator of Gestation and Cancer)
PDF [184 KB, uploaded 14 May 2017]


To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development. Moreover, hCG seems to have a potential role as an anti-rejection agent in solid organ transplantation. Future research needs to focus extensively on the functions of hCG and its receptor LH/CGR, in an effort to reveal known, as well as unknown clinical potentials. View Full-Text
Keywords: hCG; LH/CGR; ovulation induction; oocyte maturation; endometrial synchrony; immunization hCG; LH/CGR; ovulation induction; oocyte maturation; endometrial synchrony; immunization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Theofanakis, C.; Drakakis, P.; Besharat, A.; Loutradis, D. Human Chorionic Gonadotropin: The Pregnancy Hormone and More. Int. J. Mol. Sci. 2017, 18, 1059.

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