Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis

Dumnicka, Paulina; Kuśnierz-Cabala, Beata; Sporek, Mateusz; Mazur-Laskowska, Małgorzata; Gil, Krzysztof; Kuźniewski, Marek; Ceranowicz, Piotr; Warzecha, Zygmunt; Dembiński, Artur; Bonior, Joanna; Drożdż, Ryszard

doi:10.3390/ijms18040753

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Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis

Paulina Dumnicka

¹,

Beata Kuśnierz-Cabala

^2,*,

Mateusz Sporek

^3,4,

Małgorzata Mazur-Laskowska

⁵,

⁶

⁷,

⁸

⁸

⁸,

⁹

and

Ryszard Drożdż

Department of Medical Diagnostics, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland

Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15A, 31-501 Kraków, Poland

Department of Anatomy, Jagiellonian University Medical College, Kopernika 12, 31-034 Kraków, Poland

⁴

Surgery Department, The District Hospital, Szpitalna 22, 34-200 Sucha Beskidzka, Poland

⁵

Department of Diagnostics, University Hospital, Kopernika 15B, 31-501 Kraków, Poland

⁶

Department of Pathophysiology, Jagiellonian University Medical College, Czysta 18, 31-121 Kraków, Poland

⁷

Chair and Department of Nephrology, Jagiellonian University Medical College, Kopernika 15, 31-501 Kraków, Poland

⁸

Department of Physiology, Jagiellonian University Medical College, Grzegórzecka 16, 31-531 Kraków, Poland

⁹

Department of Medical Physiology, Jagiellonian University Medical College, Michałowskiego 12, 31-126 Kraków, Poland

Author to whom correspondence should be addressed.

Academic Editors: Srikumar Chellappan and Jaya Padmanabhan

Int. J. Mol. Sci. 2017, 18(4), 753; https://doi.org/10.3390/ijms18040753

Received: 24 February 2017 / Revised: 17 March 2017 / Accepted: 30 March 2017 / Published: 2 April 2017

(This article belongs to the Special Issue Pancreatic Disorders)

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Abstract

In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states. Our aim was to assess the frequency of coagulation abnormalities in the early phase of AP and evaluate the relationships between serum angiopoietin-2 and sFlt-1 and severity of coagulopathy. Sixty-nine adult patients with AP were recruited: five with SAP, 15 with moderately severe AP (MSAP) and 49 with mild AP. Six patients were diagnosed with DIC according to International Society on Thrombosis and Haemostasis (ISTH) score. All patients had at least one abnormal result of routine tests of hemostasis (low platelet count, prolonged clotting times, decreased fibrinogen, and increased D-dimer). The severity of coagulopathy correlated with AP severity according to 2012 Atlanta criteria, bedside index of severity in AP and duration of hospital stay. D-dimers correlated independently with C-reactive protein and studied markers of endothelial dysfunction. Angiopoietin-2, D-dimer, and ISTH score were best predictors of SAP, while sFlt-1 was good predictor of MSAP plus SAP. In clinical practice, routine tests of hemostasis may assist prognosis of AP. View Full-Text

Keywords: acute pancreatitis; disseminated intravascular coagulation; D-dimer; angiopoietin-2; soluble fms-like tyrosine kinase 1

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MDPI and ACS Style

Dumnicka, P.; Kuśnierz-Cabala, B.; Sporek, M.; Mazur-Laskowska, M.; Gil, K.; Kuźniewski, M.; Ceranowicz, P.; Warzecha, Z.; Dembiński, A.; Bonior, J.; Drożdż, R. Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis. Int. J. Mol. Sci. 2017, 18, 753. https://doi.org/10.3390/ijms18040753

AMA Style

Dumnicka P, Kuśnierz-Cabala B, Sporek M, Mazur-Laskowska M, Gil K, Kuźniewski M, Ceranowicz P, Warzecha Z, Dembiński A, Bonior J, Drożdż R. Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis. International Journal of Molecular Sciences. 2017; 18(4):753. https://doi.org/10.3390/ijms18040753

Chicago/Turabian Style

Dumnicka, Paulina, Beata Kuśnierz-Cabala, Mateusz Sporek, Małgorzata Mazur-Laskowska, Krzysztof Gil, Marek Kuźniewski, Piotr Ceranowicz, Zygmunt Warzecha, Artur Dembiński, Joanna Bonior, and Ryszard Drożdż. 2017. "Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis" International Journal of Molecular Sciences 18, no. 4: 753. https://doi.org/10.3390/ijms18040753

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Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis

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