Next Article in Journal
Effects of Light-Emitting Diode Irradiation on Growth Characteristics and Regulation of Porphyrin Biosynthesis in Rice Seedlings
Next Article in Special Issue
Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging
Previous Article in Journal
Moving to the Field: Plant Innate Immunity in Crop Protection
Previous Article in Special Issue
Neurogenic Effects of Ghrelin on the Hippocampus
Open AccessReview

Is Ghrelin Synthesized in the Central Nervous System?

Laboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology (IMBICE), Universidad de La Plata-Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, and Comision de Investigaciones de la Provincia de Buenos Aires (CIC), Buenos Aires 1900, Argentina
Department of Neuroscience, Brown University, Providence, RI 02912, USA
Centre Psychiatrie & Neurosciences UMR_S894 INSERM Université Paris Descartes, 75014 Paris, France
MECADEV UMR 7179 Centre National de la Recherche Scientifique, Muséum National d’Histoire Naturelle France, 91800 Brunoy, France
Author to whom correspondence should be addressed.
Academic Editor: Suzanne L. Dickson
Int. J. Mol. Sci. 2017, 18(3), 638;
Received: 7 February 2017 / Revised: 9 March 2017 / Accepted: 10 March 2017 / Published: 15 March 2017
(This article belongs to the Special Issue Neurobiological Perspectives on Ghrelin)
Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells located within the gastric oxyntic mucosa. In addition, some studies have reported that ghrelin could also be synthesized in some brain regions, such as the hypothalamus. However, evidences of neuronal production of ghrelin have been inconsistent and, as a consequence, it is still as a matter of debate if ghrelin can be centrally produced. Here, we provide a comprehensive review and discussion of the data supporting, or not, the notion that the mammalian central nervous system can synthetize ghrelin. We conclude that no irrefutable and reproducible evidence exists supporting the notion that ghrelin is synthetized, at physiologically relevant levels, in the central nervous system of adult mammals. View Full-Text
Keywords: brain; neuron; acyl-ghrelin brain; neuron; acyl-ghrelin
MDPI and ACS Style

Cabral, A.; López Soto, E.J.; Epelbaum, J.; Perelló, M. Is Ghrelin Synthesized in the Central Nervous System? Int. J. Mol. Sci. 2017, 18, 638.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop