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Cellular Reprogramming Using Protein and Cell-Penetrating Peptides

Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Jagdish Singh
Int. J. Mol. Sci. 2017, 18(3), 552; https://doi.org/10.3390/ijms18030552
Received: 26 January 2017 / Revised: 27 February 2017 / Accepted: 28 February 2017 / Published: 3 March 2017
(This article belongs to the Special Issue Cell-Penetrating Peptides 2016)
Recently, stem cells have been suggested as invaluable tools for cell therapy because of their self-renewal and multilineage differentiation potential. Thus, scientists have developed a variety of methods to generate pluripotent stem cells, from nuclear transfer technology to direct reprogramming using defined factors, or induced pluripotent stem cells (iPSCs). Considering the ethical issues and efficiency, iPSCs are thought to be one of the most promising stem cells for cell therapy. Induced pluripotent stem cells can be generated by transduction with a virus, plasmid, RNA, or protein. Herein, we provide an overview of the current technology for iPSC generation and describe protein-based transduction technology in detail. View Full-Text
Keywords: cell penetrating peptide; reprogramming; protein; iPSCs cell penetrating peptide; reprogramming; protein; iPSCs
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Seo, B.J.; Hong, Y.J.; Do, J.T. Cellular Reprogramming Using Protein and Cell-Penetrating Peptides. Int. J. Mol. Sci. 2017, 18, 552.

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