Next Article in Journal
Microglial Function across the Spectrum of Age and Gender
Next Article in Special Issue
Target Therapies for Uterine Carcinosarcomas: Current Evidence and Future Perspectives
Previous Article in Journal
Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures
Previous Article in Special Issue
Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(3), 235;

Overexpression of Transforming Acidic Coiled Coil‑Containing Protein 3 Reflects Malignant Characteristics and Poor Prognosis of Glioma

1,3,†, 1,†, 1,†, 1, 1,2, 1,3,* and 1,2,3,*
Department of Neurosurgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Science, Harbin 150086, China
Sino-Russian Medical Research Center (SRMRC) Neuroscience Institute, Harbin 150086, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: William Chi-shing Cho
Received: 23 November 2016 / Revised: 10 January 2017 / Accepted: 13 January 2017 / Published: 4 March 2017
(This article belongs to the Collection Advances in Molecular Oncology)
PDF [8769 KB, uploaded 4 March 2017]


Gliomas are malignant primary brain tumors with poor prognosis. Recently, research was indicative of a tight connection between tumor malignancy and genetic alterations. Here, we propose an oncogenic implication of transforming acidic coiled-coil-containing protein 3 (TACC3) in gliomas. By comprehensively analyzing the Chinese glioma genome atlas (CGGA) and publicly available data, we demonstrated that TACC3 were overexpressed along with glioma grade and served as an independent negative prognostic biomarker for glioma patients. Functions’ annotations and gene sets’ enrichment analysis suggested that TACC3 may participate in cell cycle, DNA repair, epithelium-mesenchymal transition and other tumor-related biological processes and molecular pathways. Patients with high TACC3 expression showed CD133+ stem cell properties, glioma plasticity and shorter overall survival time under chemo-/radio-therapy. Additionally, a TACC3 associated the miRNA-mRNA network was constructed based on in silico prediction and expression pattern, which provide a foundation for further detection of TACC3-miRNA-mRNA axis function. Collectively, our observations identify TACC3 as an oncogene of tumor malignancy, as well as a prognostic and motoring biomarker for glioma patients. View Full-Text
Keywords: glioma; TACC3; biological process; glioma stem cells glioma; TACC3; biological process; glioma stem cells

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Sun, Y.; Tian, Y.; Wang, G.-Z.; Zhao, S.-H.; Han, B.; Li, Y.-L.; Jiang, C.-L. Overexpression of Transforming Acidic Coiled Coil‑Containing Protein 3 Reflects Malignant Characteristics and Poor Prognosis of Glioma. Int. J. Mol. Sci. 2017, 18, 235.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top