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Int. J. Mol. Sci. 2017, 18(2), 368;

Twist2 Is Upregulated in Early Stages of Repair Following Acute Kidney Injury

Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO 65212, USA
Author to whom correspondence should be addressed.
Academic Editor: Monica Valentovic
Received: 18 December 2016 / Revised: 5 January 2017 / Accepted: 3 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Nephrotoxicity)
PDF [1082 KB, uploaded 13 February 2017]


The aging kidney is a marked by a number of structural and functional changes, including an increased susceptibility to acute kidney injury (AKI). Previous studies from our laboratory have shown that aging male Fischer 344 rats (24 month) are more susceptible to apoptosis-mediated injury than young counterparts. In the current studies, we examined the initial injury and early recovery phases of mercuric chloride-induced AKI. Interestingly, the aging kidney had decreased serum creatinine compared to young controls 1 day following mercuric chloride injury, but by day 4, serum creatinine was significantly elevated, suggesting that the aging kidney did not recover from injury. This conclusion is supported by the findings that serum creatinine and kidney injury molecule-1 (Kim-1) gene expression remain elevated compared to young controls at 10 days post-injury. To begin to elucidate mechanism(s) underlying dysrepair in the aging kidney, we examined the expression of Twist2, a helix-loop-helix transcription factor that may mediate renal fibrosis. Interestingly, Twist2 gene expression was elevated following injury in both young and aged rats, and Twist2 protein expression is elevated by mercuric chloride in vitro. View Full-Text
Keywords: acute kidney injury; aging; dysrepair; Kim-1; mercuric chloride; Twist2 acute kidney injury; aging; dysrepair; Kim-1; mercuric chloride; Twist2

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Grunz-Borgmann, E.A.; Nichols, L.A.; Wang, X.; Parrish, A.R. Twist2 Is Upregulated in Early Stages of Repair Following Acute Kidney Injury. Int. J. Mol. Sci. 2017, 18, 368.

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