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Obstacles to Brain Tumor Therapy: Key ABC Transporters

Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-2794, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2017, 18(12), 2544; https://doi.org/10.3390/ijms18122544
Received: 5 October 2017 / Revised: 17 November 2017 / Accepted: 22 November 2017 / Published: 27 November 2017
(This article belongs to the Special Issue Physiological and Pathological Roles of ABC Transporters)
The delivery of cancer chemotherapy to treat brain tumors remains a challenge, in part, because of the inherent biological barrier, the blood–brain barrier. While its presence and role as a protector of the normal brain parenchyma has been acknowledged for decades, it is only recently that the important transporter components, expressed in the tightly knit capillary endothelial cells, have been deciphered. These transporters are ATP-binding cassette (ABC) transporters and, so far, the major clinically important ones that functionally contribute to the blood–brain barrier are ABCG2 and ABCB1. A further limitation to cancer therapy of brain tumors or brain metastases is the blood–tumor barrier, where tumors erect a barrier of transporters that further impede drug entry. The expression and regulation of these two transporters at these barriers, as well as tumor derived alteration in expression and/or mutation, are likely obstacles to effective therapy. View Full-Text
Keywords: ABC transporter; CNS; blood–brain barrier; blood–tumor barrier; glioma; medulloblastoma; chemotherapy ABC transporter; CNS; blood–brain barrier; blood–tumor barrier; glioma; medulloblastoma; chemotherapy
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MDPI and ACS Style

Wijaya, J.; Fukuda, Y.; Schuetz, J.D. Obstacles to Brain Tumor Therapy: Key ABC Transporters. Int. J. Mol. Sci. 2017, 18, 2544. https://doi.org/10.3390/ijms18122544

AMA Style

Wijaya J, Fukuda Y, Schuetz JD. Obstacles to Brain Tumor Therapy: Key ABC Transporters. International Journal of Molecular Sciences. 2017; 18(12):2544. https://doi.org/10.3390/ijms18122544

Chicago/Turabian Style

Wijaya, Juwina, Yu Fukuda, and John D. Schuetz 2017. "Obstacles to Brain Tumor Therapy: Key ABC Transporters" International Journal of Molecular Sciences 18, no. 12: 2544. https://doi.org/10.3390/ijms18122544

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