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Int. J. Mol. Sci. 2017, 18(12), 2528; https://doi.org/10.3390/ijms18122528

Translational Aspects of Sphingolipid Metabolism in Renal Disorders

1
Department of Anatomy, Cell Biology and Physiology, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
2
Department of Medicine, Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miami, FL 33136, USA
3
Department of Radiation Oncology, Miller School of Medicine/Sylvester Cancer Center, University of Miami, Miami, FL 33136, USA
4
Department of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon
*
Author to whom correspondence should be addressed.
Received: 27 October 2017 / Revised: 16 November 2017 / Accepted: 17 November 2017 / Published: 25 November 2017
(This article belongs to the Special Issue Sphingolipids: Signals and Disease)
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Abstract

Sphingolipids, long thought to be passive components of biological membranes with merely a structural role, have proved throughout the past decade to be major players in the pathogenesis of many human diseases. The study and characterization of several genetic disorders like Fabry’s and Tay Sachs, where sphingolipid metabolism is disrupted, leading to a systemic array of clinical symptoms, have indeed helped elucidate and appreciate the importance of sphingolipids and their metabolites as active signaling molecules. In addition to being involved in dynamic cellular processes like apoptosis, senescence and differentiation, sphingolipids are implicated in critical physiological functions such as immune responses and pathophysiological conditions like inflammation and insulin resistance. Interestingly, the kidneys are among the most sensitive organ systems to sphingolipid alterations, rendering these molecules and the enzymes involved in their metabolism, promising therapeutic targets for numerous nephropathic complications that stand behind podocyte injury and renal failure. View Full-Text
Keywords: sphingolipids; Fabry’s disease; sphingolipid metabolism; podocytes; renal injury; renal failure sphingolipids; Fabry’s disease; sphingolipid metabolism; podocytes; renal injury; renal failure
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Abou Daher, A.; El Jalkh, T.; Eid, A.A.; Fornoni, A.; Marples, B.; Zeidan, Y.H. Translational Aspects of Sphingolipid Metabolism in Renal Disorders. Int. J. Mol. Sci. 2017, 18, 2528.

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