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Int. J. Mol. Sci. 2017, 18(12), 2514; https://doi.org/10.3390/ijms18122514

Models in the Research Process of Psoriasis

1
Department of Medical Biology and Genetics, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland
2
Department of Physiology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland
3
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Laboratory of Molecular Biology, Kładki 24, 80-822 Gdańsk, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 28 September 2017 / Revised: 21 November 2017 / Accepted: 22 November 2017 / Published: 24 November 2017
(This article belongs to the Special Issue Psoriasis)
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Abstract

Psoriasis is an ancient, universal chronic skin disease with a significant geographical variability, with the lowest incidence rate at the equator, increasing towards the poles. Insights into the mechanisms responsible for psoriasis have generated an increasing number of druggable targets and molecular drugs. The development of relevant in vitro and in vivo models of psoriasis is now a priority and an important step towards its cure. In this review, we summarize the current cellular and animal systems suited to the study of psoriasis. We discuss the strengths and limitations of the various models and the lessons learned. We conclude that, so far, there is no one model that can meet all of the research needs. Therefore, the choice model system will depend on the questions being addressed. View Full-Text
Keywords: psoriasis; disease models; pathomechanism; biomedical tools; drug-development psoriasis; disease models; pathomechanism; biomedical tools; drug-development
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bocheńska, K.; Smolińska, E.; Moskot, M.; Jakóbkiewicz-Banecka, J.; Gabig-Cimińska, M. Models in the Research Process of Psoriasis. Int. J. Mol. Sci. 2017, 18, 2514.

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