Models in the Research Process of Psoriasis
Abstract
:1. Psoriasis and Research of This Disease
2. In Vitro Models
2.1. Two-Dimensional (2D) Engineered Skin Psoriatic Cell Model
2.2. Reconstituted Human Epidermal Models (3D)
3. BioMAP Model
4. Ex Vivo Models
5. In Vivo Models
5.1. Spontaneous Mouse Models
5.2. Genetically Engineered Mouse Models
5.3. Xenotransplantations Models
5.4. Direct Induction
6. Conclusions
Acknowledgments
Conflicts of Interest
References
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Features | In Vitro Models | In Vivo Models |
---|---|---|
Pros | Easy access to cells Reduced complexity Utilization of human tissue Avoids the need for animals Individual cell responses can be measured | Similar and complex histopathological image Large amount of interacting factors and signaling pathways for manipulation studies or new drugs testing Varied amount of modifications, depending on the purpose of research |
Cons | Excludes microenvironment influences and might be misleading Excludes macroenvironmental influences | Differences between human and animal skin and immunity Limitation resulting from the polygene nature of the disease—difficulties in a complete phenotype reconstruction by single mutation Influence of environmental factors |
Best use of model | Evaluation of cell physiology, viability, phenotype, function, and responses to stimulators and inhibitors | Suitable for research the multifarious interactions between skin cells, vascular endothelium and immune response |
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Bocheńska, K.; Smolińska, E.; Moskot, M.; Jakóbkiewicz-Banecka, J.; Gabig-Cimińska, M. Models in the Research Process of Psoriasis. Int. J. Mol. Sci. 2017, 18, 2514. https://doi.org/10.3390/ijms18122514
Bocheńska K, Smolińska E, Moskot M, Jakóbkiewicz-Banecka J, Gabig-Cimińska M. Models in the Research Process of Psoriasis. International Journal of Molecular Sciences. 2017; 18(12):2514. https://doi.org/10.3390/ijms18122514
Chicago/Turabian StyleBocheńska, Katarzyna, Elwira Smolińska, Marta Moskot, Joanna Jakóbkiewicz-Banecka, and Magdalena Gabig-Cimińska. 2017. "Models in the Research Process of Psoriasis" International Journal of Molecular Sciences 18, no. 12: 2514. https://doi.org/10.3390/ijms18122514