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Int. J. Mol. Sci. 2017, 18(10), 2166; https://doi.org/10.3390/ijms18102166

Human Chorionic Gonadotropin as a Pivotal Endocrine Immune Regulator Initiating and Preserving Fetal Tolerance

Experimental Obstetrics and Gynecology, Medical Faculty, GC-I3, Otto-von-Guericke University Magdeburg, 39108 Magdeburg, Germany
Received: 29 September 2017 / Revised: 13 October 2017 / Accepted: 16 October 2017 / Published: 17 October 2017
(This article belongs to the Special Issue hCG—An Endocrine, Regulator of Gestation and Cancer)
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Abstract

The pregnancy hormone, human chorionic gonadotropin (hCG), is crucially involved in processes such as implantation and placentation, two milestones of pregnancy whose successful progress is a prerequisite for adequate fetal growth. Moreover, hCG determines fetal fate by regulating maternal innate and adaptive immune responses allowing the acceptance of the foreign fetal antigens. As one of the first signals provided by the embryo to its mother, hCG has the potential to regulate very early pregnancy-driven immune responses, allowing the establishment and preservation of fetal tolerance. This mini review focuses on how hCG modulates the adaptive arm of the immune system including dendritic cells as key regulators of adaptive immune responses. View Full-Text
Keywords: human chorionic gonadotropin; dendritic cells; regulatory T cells; B cells; fetal tolerance human chorionic gonadotropin; dendritic cells; regulatory T cells; B cells; fetal tolerance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Schumacher, A. Human Chorionic Gonadotropin as a Pivotal Endocrine Immune Regulator Initiating and Preserving Fetal Tolerance. Int. J. Mol. Sci. 2017, 18, 2166.

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