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Review

Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications

1
Biomedical Section, Stem Cells Unit, Tecnologica Research Institute, 88900 Crotone, Italy
2
Unit of Craniomaxillofacial Surgery, Calabrodental, 88900 Crotone, Italy
3
Unit of Experimental Medicine, Marrelli Hospital, 88900 Crotone, Italy
4
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80138 Naples, Italy
5
Professeur Emerite, Biomédicale des Saints Pères, Université Paris Descartes, Institut National de la Santé et de la Recherche Médicale UMR-S 1124, 75654 Paris, France
*
Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Int. J. Mol. Sci. 2017, 18(10), 2140; https://doi.org/10.3390/ijms18102140
Received: 2 August 2017 / Revised: 11 October 2017 / Accepted: 11 October 2017 / Published: 13 October 2017
Bone regeneration in craniomaxillofacial surgery represents an issue that involves both surgical and aesthetic aspects. The most recent studies on bone tissue engineering involving adipose-derived stromal/stem cells (ASCs) have clearly demonstrated that such cells can play a crucial role in the treatment of craniomaxillofacial defects, given their strong commitment towards the osteogenic phenotype. A deeper knowledge of the molecular mechanisms underlying ASCs is crucial for a correct understanding of the potentialities of ASCs-based therapies in the most complex maxillofacial applications. In this topical review, we analyzed the molecular mechanisms of ASCs related to their support toward angiogenesis and osteogenesis, during bone regeneration. Moreover, we analyzed both case reports and clinical trials reporting the most promising clinical applications of ASCs in the treatment of craniomaxillofacial defects. Our study aimed to report the main molecular and clinical features shown by ASCs, used as a therapeutic support in bone engineering, as compared to the use of conventional autologous and allogeneic bone grafts. View Full-Text
Keywords: adipose-derived stromal/stem cells (ASCs); craniomaxillofacial bone defects; bone tissue engineering; bone defects; molecular mechanism; clinical trials; surgical reconstruction adipose-derived stromal/stem cells (ASCs); craniomaxillofacial bone defects; bone tissue engineering; bone defects; molecular mechanism; clinical trials; surgical reconstruction
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MDPI and ACS Style

Paduano, F.; Marrelli, M.; Amantea, M.; Rengo, C.; Rengo, S.; Goldberg, M.; Spagnuolo, G.; Tatullo, M. Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications. Int. J. Mol. Sci. 2017, 18, 2140. https://doi.org/10.3390/ijms18102140

AMA Style

Paduano F, Marrelli M, Amantea M, Rengo C, Rengo S, Goldberg M, Spagnuolo G, Tatullo M. Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications. International Journal of Molecular Sciences. 2017; 18(10):2140. https://doi.org/10.3390/ijms18102140

Chicago/Turabian Style

Paduano, Francesco, Massimo Marrelli, Massimiliano Amantea, Carlo Rengo, Sandro Rengo, Michel Goldberg, Gianrico Spagnuolo, and Marco Tatullo. 2017. "Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications" International Journal of Molecular Sciences 18, no. 10: 2140. https://doi.org/10.3390/ijms18102140

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