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Int. J. Mol. Sci. 2017, 18(10), 2132;

The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment

Key Laboratory for Space Bioscience and Biotechnology, Bone Metabolism Lab, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China
Author to whom correspondence should be addressed.
Received: 31 August 2017 / Revised: 28 September 2017 / Accepted: 9 October 2017 / Published: 12 October 2017
(This article belongs to the Special Issue Oxidative Stress and Space Biology: An Organ-Based Approach)
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The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut’s health. Bone loss is one of the most significant alterations in mammalians after long-duration habitation in space. In this review, we summarize the crucial roles of major factors—namely radiation and microgravity—in space in oxidative stress generation in living organisms, and the inhibitory effect of oxidative stress on bone formation. We discussed the possible mechanisms of oxidative stress-induced skeletal involution, and listed some countermeasures that have therapeutic potentials for bone loss via oxidative stress antagonism. Future research for better understanding the oxidative stress caused by space environment and the development of countermeasures against oxidative damage accordingly may facilitate human beings to live more safely in space and explore deeper into the universe. View Full-Text
Keywords: oxidative stress; bone loss; microgravity; radiation; countermeasure oxidative stress; bone loss; microgravity; radiation; countermeasure

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tian, Y.; Ma, X.; Yang, C.; Su, P.; Yin, C.; Qian, A.-R. The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment. Int. J. Mol. Sci. 2017, 18, 2132.

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