Next Article in Journal
Angiogenesis Inhibitors in NSCLC
Next Article in Special Issue
Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
Previous Article in Journal
Cultivar and Metal-Specific Effects of Endophytic Bacteria in Helianthus tuberosus Exposed to Cd and Zn
Previous Article in Special Issue
“Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer
Open AccessReview

Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation

1
Novartis Institutes for BioMedical Research, WSJ-386, CH-4002 Basel, Switzerland
2
School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(10), 2027; https://doi.org/10.3390/ijms18102027
Received: 23 August 2017 / Revised: 10 September 2017 / Accepted: 18 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Sphingolipids: Signals and Disease)
Allogeneic haemopoietic stem cell transplantation (HSCT) is increasingly used to treat haematological malignant diseases via the graft-versus-leukaemia (GvL) or graft-versus-tumour effects. Although improvements in infectious disease prophylaxis, immunosuppressive treatments, supportive care, and molecular based tissue typing have contributed to enhanced outcomes, acute graft-versus-host disease and other transplant related complications still contribute to high mortality and significantly limit the more widespread use of HSCT. Sphingosine 1-phosphate (S1P) is a zwitterionic lysophospholipid that has been implicated as a crucial signaling regulator in many physiological and pathophysiological processes including multiple cell types such as macrophages, dendritic cells, T cells, T regulatory cells and endothelial cells. Recent data suggested important roles for S1P signaling in engraftment, graft-versus-host disease (GvHD), GvL and other processes that occur during and after HSCT. Based on such data, pharmacological intervention via S1P modulation may have the potential to improve patient outcome by regulating GvHD and enhancing engraftment while permitting effective GvL. View Full-Text
Keywords: sphingosine 1-phosphate, haemopoietic stem cell transplantation, graft-versus-host disease, graft versus leukaemia sphingosine 1-phosphate, haemopoietic stem cell transplantation, graft-versus-host disease, graft versus leukaemia
Show Figures

Figure 1

MDPI and ACS Style

Smith, P.; O’Sullivan, C.; Gergely, P. Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation. Int. J. Mol. Sci. 2017, 18, 2027.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop