Next Article in Journal
Osteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher Disease
Next Article in Special Issue
Effects and Side Effects of Using Sorafenib and Sunitinib in the Treatment of Metastatic Renal Cell Carcinoma
Previous Article in Journal
New Irradiation Method with Indocyanine Green-Loaded Nanospheres for Inactivating Periodontal Pathogens
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(1), 151;

Bone Niches, Hematopoietic Stem Cells, and Vessel Formation

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy
National Cancer Institute Giovanni Paolo II, 70124 Bari, Italy
Author to whom correspondence should be addressed.
Academic Editors: Girolamo Ranieri and Yogesh Kumar Vashist
Received: 25 October 2016 / Revised: 14 December 2016 / Accepted: 9 January 2017 / Published: 13 January 2017
Full-Text   |   PDF [1077 KB, uploaded 13 January 2017]   |  


Bone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in both the endosteum, in the so-called endosteal niche, and close to thin-walled and fenestrated sinusoidal vessel in the center of BM, in the so-called vascular niche. HSCs give rise to all types of mature blood cells through a process finely controlled by numerous signals emerging from the bone marrow niches where HSCs reside. This review will focus on the description of the role of BM niches in the control of the fate of HSCs and will also highlight the role of the BM niches in the regulation of vasculogenesis and angiogenesis. Moreover, alterations of the signals in niche microenvironment are involved in many aspects of tumor progression and vascularization and further knowledge could provide the basis for the development of new therapeutic strategies. View Full-Text
Keywords: angiogenesis; bone marrow; endosteal niche; hematopoietic stem cells; vascular niche; vasculogenesis angiogenesis; bone marrow; endosteal niche; hematopoietic stem cells; vascular niche; vasculogenesis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Tamma, R.; Ribatti, D. Bone Niches, Hematopoietic Stem Cells, and Vessel Formation. Int. J. Mol. Sci. 2017, 18, 151.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top