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Int. J. Mol. Sci. 2017, 18(1), 102;

Unconventional Pathways of Secretion Contribute to Inflammation

Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK
Author to whom correspondence should be addressed.
Academic Editors: Gian-Pietro Di Sansebastiano and Antonio Gaballo
Received: 29 November 2016 / Revised: 16 December 2016 / Accepted: 30 December 2016 / Published: 5 January 2017
(This article belongs to the Special Issue Unconventional Proteins and Membranes Traffic)
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In the conventional pathway of protein secretion, leader sequence-containing proteins leave the cell following processing through the endoplasmic reticulum (ER) and Golgi body. However, leaderless proteins also enter the extracellular space through mechanisms collectively known as unconventional secretion. Unconventionally secreted proteins often have vital roles in cell and organism function such as inflammation. Amongst the best-studied inflammatory unconventionally secreted proteins are interleukin (IL)-1β, IL-1α, IL-33 and high-mobility group box 1 (HMGB1). In this review we discuss the current understanding of the unconventional secretion of these proteins and highlight future areas of research such as the role of nuclear localisation. View Full-Text
Keywords: unconventional secretion; nuclear localisation; inflammasome; IL-1β; IL-1α; IL-33; HMGB1 unconventional secretion; nuclear localisation; inflammasome; IL-1β; IL-1α; IL-33; HMGB1

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Daniels, M.J.D.; Brough, D. Unconventional Pathways of Secretion Contribute to Inflammation. Int. J. Mol. Sci. 2017, 18, 102.

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