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Int. J. Mol. Sci. 2017, 18(1), 1;

CD11c+ CD8+ T Cells Reduce Renal Fibrosis Following Ureteric Obstruction by Inducing Fibroblast Apoptosis

College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, China
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China
Department of Geriatrics, Tongji Hospital of Shanghai affiliated to Tongji University, Shanghai 20065, China
The Beijing Institute of Heart Lung and Blood Vessel Diseases, Chaoyang, Beijing 100029, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 10 October 2016 / Revised: 5 December 2016 / Accepted: 11 December 2016 / Published: 22 December 2016
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
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Tubulointerstitial fibrosis is a common consequence of various kidney diseases that lead to end-stage renal failure, and lymphocyte infiltration plays an important role in renal fibrosis. We previously found that depletion of cluster of differentiation 8+ (CD8+) T cells increases renal fibrosis following ureteric obstruction, and interferon-γ (IFN-γ)-expressing CD8+ T cells contribute to this process. CD8+ T cells are cytotoxic T cells; however, whether their cytotoxic effect reduces fibrosis remains unknown. This study showed that CD8+ T cells isolated from obstructed kidney showed mRNA expression of the cytotoxicity-related genes perforin 1, granzyme A, granzyme B, and FAS ligand; additionally, CD8 knockout significantly reduced the expression levels of these genes in obstructed kidney. Infiltrated CD8+ T cells were distributed around fibroblasts, and they are associated with fibroblast apoptosis in obstructed kidney. Moreover, CD11c+ CD8+ T cells expressed higher levels of the cytotoxicity-related genes than CD11c CD8+ T cells, and infiltrated CD11c+ CD8+ T cells in obstructed kidney could induce fibroblast death in vitro. Results indicated that induction of fibroblast apoptosis partly contributed to the effect of CD8+ T cells on reduction of renal fibrosis. Given that inflammatory cells are involved in fibrosis, our results suggest that kidney fibrosis is a multifactorial process involving different arms of the immune system. View Full-Text
Keywords: T cells; fibroblasts; fibrosis; inflammation; kidney T cells; fibroblasts; fibrosis; inflammation; kidney

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, H.; Wang, J.; Bai, Y.; Li, J.; Li, L.; Dong, Y. CD11c+ CD8+ T Cells Reduce Renal Fibrosis Following Ureteric Obstruction by Inducing Fibroblast Apoptosis. Int. J. Mol. Sci. 2017, 18, 1.

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