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Int. J. Mol. Sci. 2016, 17(7), 1054;

Compound K Attenuates the Development of Atherosclerosis in ApoE−/− Mice via LXRα Activation

Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Shapingba, Chongqing 400038, China
Department of pharmacy, Xinqiao Hospital & The Second Affiliated Hospital, Third Military Medical University, Shapingba, Chongqing 400037, China
Department of Outpatient, Logistical Engineering University of PLA, Shapingba, Chongqing 401311, China
These authors contributed equally to this work
Authors to whom correspondence should be addressed.
Academic Editors: Michael Henein and Maurizio Battino
Received: 14 April 2016 / Revised: 27 June 2016 / Accepted: 28 June 2016 / Published: 8 July 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
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Background: Atherosclerosis is a fundamental pathological process responded to some serious cardiovascular events. Although the cholesterol-lowering drugs are widely prescribed for atherosclerosis therapy, it is still the leading cause of death in the developed world. Here we measured the effects of compound K in atherosclerosis formation and investigated the probably mechanisms of the anti-antherosclerosis roles of compound K. Methods: We treated the atherosclerotic model animals (apoE−/− mice on western diet) with compound K and measured the size of atherosclerotic lesions, inflammatory cytokine levels and serum lipid profile. Peritoneal macrophages were collected in vitro for the foam cell and inflammasome experiments. Results: Our results show that treatment with compound K dose-dependently attenuates the formation of atherosclerotic plaques by 55% through activation of reverse cholesterol transport pathway, reduction of systemic inflammatory cytokines and inhibition of local inflammasome activity. Compound K increases the cholesterol efflux of macrophage-derived foam cells, and reduces the inflammasome activity in cholesterol crystal stimulated macrophages. The activation of LXRα may contribute to the athero-protective effects of compound K. Conclusion: These observations provide evidence for an athero-protective effect of compound K via LXRα activation, and support its further evaluation as a potential effective modulator for the prevention and treatment of atherosclerosis. View Full-Text
Keywords: atherosclerosis; compound K; reverse cholesterol transport; inflammasome; LXRα atherosclerosis; compound K; reverse cholesterol transport; inflammasome; LXRα

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Zhou, L.; Zheng, Y.; Li, Z.; Bao, L.; Dou, Y.; Tang, Y.; Zhang, J.; Zhou, J.; Liu, Y.; Jia, Y.; Li, X. Compound K Attenuates the Development of Atherosclerosis in ApoE−/− Mice via LXRα Activation. Int. J. Mol. Sci. 2016, 17, 1054.

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