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Int. J. Mol. Sci. 2016, 17(6), 907;

Reconstruction and Application of Protein–Protein Interaction Network

Tianjin Key Laboratory of Animal and Plant Resistance/College of Life Sciences, Tianjin Normal University, Tianjin 300387, China
Tianjin Aquatic Animal Infectious Disease Control and Prevention Center, Tianjin 300221, China
Author to whom correspondence should be addressed.
Academic Editor: Tatyana Karabencheva-Christova
Received: 2 April 2016 / Revised: 31 May 2016 / Accepted: 3 June 2016 / Published: 8 June 2016
(This article belongs to the Collection Proteins and Protein-Ligand Interactions)
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The protein-protein interaction network (PIN) is a useful tool for systematic investigation of the complex biological activities in the cell. With the increasing interests on the proteome-wide interaction networks, PINs have been reconstructed for many species, including virus, bacteria, plants, animals, and humans. With the development of biological techniques, the reconstruction methods of PIN are further improved. PIN has gradually penetrated many fields in biological research. In this work we systematically reviewed the development of PIN in the past fifteen years, with respect to its reconstruction and application of function annotation, subsystem investigation, evolution analysis, hub protein analysis, and regulation mechanism analysis. Due to the significant role of PIN in the in-depth exploration of biological process mechanisms, PIN will be preferred by more and more researchers for the systematic study of the protein systems in various kinds of organisms. View Full-Text
Keywords: protein–protein interaction network; reconstruction technique; interactome; proteome protein–protein interaction network; reconstruction technique; interactome; proteome

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Hao, T.; Peng, W.; Wang, Q.; Wang, B.; Sun, J. Reconstruction and Application of Protein–Protein Interaction Network. Int. J. Mol. Sci. 2016, 17, 907.

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