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The MicroRNA-21 in Autoimmune Diseases

Shenzhen Laboratory of Fully Human Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
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Academic Editor: Y-h. Taguchi
Int. J. Mol. Sci. 2016, 17(6), 864; https://doi.org/10.3390/ijms17060864
Received: 10 April 2016 / Revised: 18 May 2016 / Accepted: 30 May 2016 / Published: 3 June 2016
(This article belongs to the Special Issue MicroRNA Regulation)
MicroRNA-21 (miR-21) is an oncomiR and significantly upregulated in a wide range of cancers. It is strongly involved in apoptosis and oncogenesis, since most of its reported targets are tumor suppressors. Recently, miR-21 was found to be correlated with the pathogenesis of autoimmune diseases and may play an essential role in regulating autoimmune responses. In particular, miR-21 promotes Th17 cell differentiation, which mediates the development of multiple autoimmune diseases. In this article, we review the current research on the mechanisms that regulate miR-21 expression, the potential of miR-21 as a diagnostic biomarker for autoimmune disease and the mechanisms by which miR-21 promotes the development of autoimmune disease. We also discussed the therapeutic potential of targeting miR-21 in treating patients with autoimmune disease. View Full-Text
Keywords: miR-21; autoimmune disease; Th17; apoptosis miR-21; autoimmune disease; Th17; apoptosis
MDPI and ACS Style

Wang, S.; Wan, X.; Ruan, Q. The MicroRNA-21 in Autoimmune Diseases. Int. J. Mol. Sci. 2016, 17, 864.

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