The MicroRNA-21 in Autoimmune Diseases
AbstractMicroRNA-21 (miR-21) is an oncomiR and significantly upregulated in a wide range of cancers. It is strongly involved in apoptosis and oncogenesis, since most of its reported targets are tumor suppressors. Recently, miR-21 was found to be correlated with the pathogenesis of autoimmune diseases and may play an essential role in regulating autoimmune responses. In particular, miR-21 promotes Th17 cell differentiation, which mediates the development of multiple autoimmune diseases. In this article, we review the current research on the mechanisms that regulate miR-21 expression, the potential of miR-21 as a diagnostic biomarker for autoimmune disease and the mechanisms by which miR-21 promotes the development of autoimmune disease. We also discussed the therapeutic potential of targeting miR-21 in treating patients with autoimmune disease. View Full-Text
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Wang, S.; Wan, X.; Ruan, Q. The MicroRNA-21 in Autoimmune Diseases. Int. J. Mol. Sci. 2016, 17, 864.
Wang S, Wan X, Ruan Q. The MicroRNA-21 in Autoimmune Diseases. International Journal of Molecular Sciences. 2016; 17(6):864.Chicago/Turabian Style
Wang, Shaowen; Wan, Xiaochun; Ruan, Qingguo. 2016. "The MicroRNA-21 in Autoimmune Diseases." Int. J. Mol. Sci. 17, no. 6: 864.
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