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Int. J. Mol. Sci. 2016, 17(5), 660;

Association of the MicroRNA-146a SNP rs2910164 with Ischemic Stroke Incidence and Prognosis in a Chinese Population

Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, 167 Beilishilu, Beijing 100037, China
Department of Hematology, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing 101149, China
These authors contributed equally to this study.
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 9 March 2016 / Revised: 12 April 2016 / Accepted: 23 April 2016 / Published: 5 May 2016
(This article belongs to the Special Issue MicroRNA in Various Disease States as Biomarkers)
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We conducted a case-control study investigating the association between the single-nucleotide polymorphism rs2910164 in microRNA (miR)-146a and the risk and prognosis of stroke. We recruited a total of 1139 ischemic stroke patients and 1585 sex- and age-matched control subjects. After a median follow-up period of 4.5 years, 1071 of these ischemic stroke patients were then recruited for a prospective study. Our study revealed that rs2910164 was not associated with ischemic stroke incidence (odds ratio = 1.00; 95% confidence interval (CI) = 0.80–1.24; p = 0.985) by multivariate logistic regression. Meta-analysis of our case-control study and three others on Asian populations also suggested that there was no relationship between rs2910164 and ischemic stroke incidence. The significance of differences in long-term outcomes was examined by the log-rank test of the respective comparison groups. The prospective study showed that rs2910164 led to a 1.56-fold increased risk of stroke recurrence (hazard ratio (HR) = 1.56; 95% CI = 1.10–2.20; p = 0.013) and a 2.13-fold increased risk of death caused by cardiovascular disease or stroke (Csdeath) (HR = 2.13; 95% CI = 1.31–3.46; p = 0.002). The independent association of rs2910164 with stroke prognosis was evaluated using Cox regression models. Therefore, rs2910164 appears to be a strong predictor of stroke prognosis but not of stroke incidence in Asian populations. View Full-Text
Keywords: incidence; miR-146a; polymorphisms; prognosis; stroke incidence; miR-146a; polymorphisms; prognosis; stroke

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Qu, J.-Y.; Xi, J.; Zhang, Y.-H.; Zhang, C.-N.; Song, L.; Song, Y.; Hui, R.-T.; Chen, J.-Z. Association of the MicroRNA-146a SNP rs2910164 with Ischemic Stroke Incidence and Prognosis in a Chinese Population. Int. J. Mol. Sci. 2016, 17, 660.

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