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Int. J. Mol. Sci. 2016, 17(5), 644;

Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages

Ludwig Maximilians Universität München, Frauenklinik Campus Innenstadt, Maistrasse 11, 80337 München, Germany
Author to whom correspondence should be addressed.
Academic Editor: Cheorl-Ho Kim
Received: 29 January 2016 / Revised: 14 April 2016 / Accepted: 22 April 2016 / Published: 28 April 2016
(This article belongs to the Special Issue Glycan–Receptor Interaction)
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Galectins are galactose binding proteins and, in addition, factors for a wide range of pathologies in pregnancy. We have analyzed the expression of prototype (gal-1, -2, -7, -10) and chimera-type (gal-3) galectins in the placenta in cases of spontaneous abortions (SPA) and recurrent abortions (RA) in the first trimester. Fifteen placental samples from healthy pregnancies were used as a control group. Nine placentas were examined for spontaneous abortions, and 12 placentas for recurrent abortions. For differentiation and evaluation of different cell types of galectin-expression in the decidua, immunofluorescence was used. For all investigated prototype galectins (gal-1, -2, -7, -10) in SPA and RA placenta trophoblast cells the expression is significantly decreased. In the decidua/extravillous trophoblast only gal-2 expression was significantly lowered, which could be connected to its role in angiogenesis. In trophoblasts in first-trimester placentas and in cases of SPA and RA, prototype galectins are altered in the same way. We suspect prototype galectins have a similar function in placental tissue because of their common biochemical structure. Expression of galectin 3 as a chimera type galectin was not found to be significantly altered in abortive placentas. View Full-Text
Keywords: galectins; placenta; trophoblast; decidua; spontaneous and recurrent miscarriage galectins; placenta; trophoblast; decidua; spontaneous and recurrent miscarriage

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Unverdorben, L.; Haufe, T.; Santoso, L.; Hofmann, S.; Jeschke, U.; Hutter, S. Prototype and Chimera-Type Galectins in Placentas with Spontaneous and Recurrent Miscarriages. Int. J. Mol. Sci. 2016, 17, 644.

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