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Int. J. Mol. Sci. 2016, 17(4), 589;

Phytochemical and Pharmacological Profiles of Three Fagopyrum Buckwheats

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 26 January 2016 / Revised: 15 March 2016 / Accepted: 11 April 2016 / Published: 19 April 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
Full-Text   |   PDF [1617 KB, uploaded 19 April 2016]   |  


The genus Fagopyrum (Polygonaceae), currently comprising 15 species of plants, includes three important buckwheat species: Fagopyrum esculentum (F. esculentum) Moench. (common buckwheat), Fagopyrum tataricum (F. tataricum) (L.) Gaertn. (tartary buckwheat) and Fagopyrum dibotrys (F. dibotrys) (D. Don) Hara. (perennial buckwheat), which have been well explored due to their long tradition of both edible and medicinal use. This review aimed to present an up-to-date and comprehensive analysis of the phytochemistry and pharmacology of the three Fagopyrum buckwheats. In addition, the scope for future research was also discussed. All available references included in this paper were compiled from major databases, such as MEDLINE, Pubmed, Scholar, Elsevier, Springer, Wiley and CNKI. A total of 106 compounds isolated from three Fagopyrum buckwheats can be mainly divided into six classes: flavonoids, phenolics, fagopyritols, triterpenoids, steroids and fatty acids. Flavonoids and phenolic compounds were considered to be the major active components. Considerable pharmacological experiments both in vitro and in vivo have validated that Fagopyrum buckwheats possess antitumor, anti-oxidant, anti-inflammatory, hepatoprotective, anti-diabetic activities, etc. All reported data lead us to conclude that Fagopyrum buckwheats have convincing medicinal potential. However, further research is needed to explore its bioactive constituents, the relationship to their structural activities and the molecular mechanisms of action. View Full-Text
Keywords: Fagopyrum; buckwheat; phytochemistry; pharmacology Fagopyrum; buckwheat; phytochemistry; pharmacology

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Jing, R.; Li, H.-Q.; Hu, C.-L.; Jiang, Y.-P.; Qin, L.-P.; Zheng, C.-J. Phytochemical and Pharmacological Profiles of Three Fagopyrum Buckwheats. Int. J. Mol. Sci. 2016, 17, 589.

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