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Int. J. Mol. Sci. 2016, 17(2), 202;

Molecular Mechanisms of Nickel Allergy

Department of Oral Molecular Pathology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Tokushima 770-8504, Japan
Author to whom correspondence should be addressed.
Academic Editor: Reinhard Dallinger
Received: 15 January 2016 / Revised: 29 January 2016 / Accepted: 29 January 2016 / Published: 2 February 2016
(This article belongs to the Special Issue Metal Metabolism in Animals)
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Allergic contact hypersensitivity to metals is a delayed-type allergy. Although various metals are known to produce an allergic reaction, nickel is the most frequent cause of metal allergy. Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. In addition, the adsorption and excretion of various metals, in particular nickel, is discussed to further understand the pathogenesis of metal allergy. View Full-Text
Keywords: metal allergy; Ni; DTH; DC; T cell; TLR; TSLP metal allergy; Ni; DTH; DC; T cell; TLR; TSLP

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Saito, M.; Arakaki, R.; Yamada, A.; Tsunematsu, T.; Kudo, Y.; Ishimaru, N. Molecular Mechanisms of Nickel Allergy. Int. J. Mol. Sci. 2016, 17, 202.

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